ArticleAmerican journal of translational research2018
A novel hybrid 3D-printed titanium scaffold for osteogenesis in a rabbit calvarial defect model.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Forged to heal: The role of metallic cellular solids in bone tissue engineering.Materials today. Bio · 2023Article
- Evaluation of Gelatin/Hyaluronic Acid-Generated Bridging in a 3D-Printed Titanium Cage for Bone Regeneration.Journal of functional biomaterials · 2023Article
- A Review of 3D Printed Bone Implants.Micromachines · 2022Review
- Stem Cell Fate and Immunomodulation Promote Bone RegenerationFrontiers in bioengineering and biotechnology · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Surface-treated 3D printed Ti-6Al-4V scaffolds with enhanced bone regeneration performance: anAnnals of translational medicine · 2021Article
- Strontium-substituted hydroxyapatite stimulates osteogenesis on poly(propylene fumarate) nanocomposite scaffolds.Journal of biomedical materials research. Part A · 2019Article
- Article
- Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction.RSC advances · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to explore an innovative method to improve the osteogenic ability of porous titanium. We used gelatin (Gel) and nano-hydroxyapatite (nHA) to construct micro-scaffolds within the pores of porous titanium alloy. We compared three groups: control, Gel:nHA = 1:0, and Gel:nHA = 1:1. We assessed cell attachment, cell proliferation, and osteogenic (alkaline phosphatase [ALP] and collagen type 1 [Col-1]) and cytoskeletal (Talin) gene and protein expression in MC3T3-E1 cells. We also evaluated osteogenic abilities in a rabbit calvarial defect model. Our results showed that micro-scaffolds can improve new bone formation both in vitro and in vivo. Between the two micro-scaffold groups, the Gel:nHA = 1:1 group exhibited the most satisfactory results. It had a multi-hierarchical pore structure with a mean pore size of 156±86 μm. The Gel:nHA = 1:1 group exhibited significantly higher gene and protein expression of ALP, Col-1, and Talin. This group also exhibited the most new bone volume during in vivo experiments. The 3D micro-scaffold structure was an effective method of porous titanium modification that not only provided appropriate cell growth conditions but may also be used as a carrier of bioactive factors in the future.
Indexed as
Identifiers
29511441PMC5835812W3015821022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.