SynthesisNature communications2018
Genome-wide analysis yields new loci associating with aortic valve stenosis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 10 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 10 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.Circulation · 2026Pooled it
- Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Nature genetics · 2026Pooled it
- Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.Genomics, proteomics & bioinformatics · 2025Pooled it
- Pooled it
- Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.Nature communications · 2024Pooled it
- Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis.Cardiovascular research · 2023Pooled it
- Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.European heart journal · 2023Pooled it
- Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes.Circulation. Genomic and precision medicine · 2023Pooled it
- Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology · 2021Pooled it
- Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis.International journal of cardiology · 2019Pooled it
- FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.Circulation. Genomic and precision medicine · 2020Trial
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- The functional landscape of coding variation in the familial hypercholesterolemia geneScience (New York, N.Y.) · 2026Article
- Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.Nature genetics · 2026Article
- Lipoprotein(a) and calcific aortic stenosis: from inherited risk marker to therapeutic target.Frontiers in medicine · 2026Review
- Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study.NPJ cardiovascular health · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Association Between Inflammatory Arthritis, Genetic Risk, and the Long-Term Risk of Degenerative Aortic Stenosis: A Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- Calcific aortic stenosis: omics-based target discovery and therapy development.European heart journal · 2025Review
- Causal effect of psoriasis on aortic valve stenosis: a two-sample Mendelian randomization study.Journal of geriatric cardiology : JGC · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 12 institutions in 6 countries.
Anna HelgadottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. anna.helgadottir@decode.is.ORCID http://orcid.org/0000-0002-1806-2467
Gudmar ThorleifssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Solveig GretarsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Olafur A StefanssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Vinicius TragantedeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Rosa B ThorolfsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Ingileif JonsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Thorsteinn BjornssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands.
Jonas B NielsenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, MI, USA.ORCID http://orcid.org/0000-0002-6654-2852
Wei ZhouDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, MI, USA.
Lasse FolkersenCardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
Andreas MartinssonDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, 22185, Sweden.
Mahyar HeydarpourDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Siddharth PrakashDepartment of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Gylfi OskarssonChildrens Hospital, Landspitali National University Hospital of Iceland, Reykjavik, 101, Iceland.
Tomas GudbjartssonDepartment of Surgery and Cardiothoracic Surgery, Landspitali National University Hospital, Reykjavik, 101, Iceland.
Arnar GeirssonSection of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, 06510, CT, USA.
Isleifur OlafssonDepartment of Clinical Biochemistry, Landspitali National University Hospital, Reykjavik, 101, Iceland.
Emil L SigurdssonHeilsugaeslan Solvangi, Hafnarfjördur, 220, Iceland.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, 22185, Sweden.ORCID http://orcid.org/0000-0002-0473-0241
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, 22185, Sweden.
Anders Franco-CerecedaCardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
Lars FritscheHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7491, Norway.
Maoxuan LinDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, MI, USA.
Bo YangDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, 48105, USA.
Whitney HornsbyFrankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Dongchuan GuoDepartment of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Chad M BrummettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, 48105, USA.
Gonçalo AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Michael MathisDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, 48105, USA.
Dianna MilewiczDepartment of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Simon C BodyDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Per ErikssonCardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7491, Norway.
Christopher Newton-ChehMedical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, 22185, Sweden.
Ragnar DanielsenFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Gudmundur ThorgeirssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. kstefans@decode.is.
deCODE Genetics (Iceland) · ISUniversity of Michigan · USKarolinska University Hospital · SELund University · SENational University Hospital of Iceland · ISBrigham and Women's Hospital · USBroad Institute · USNorwegian University of Science and Technology · NOThe University of Texas Health Science Center at Houston · USUniversity of Iceland · ISSt. Luke's Episcopal Hospital · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MCenter for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4MUsing genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MUsing Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4MGenetic Etiology of Bicuspid Aortic Valve DiseaseR01HL114823 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BODY, SIMON C · 2012 to 2016
$2.1MLarge-scale human genetics to understand molecular mechanisms of atrial fibrillation and related traitsR01HL130705 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2016 to 2016
$741kNCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL114823NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL130705NHLBI NIH HHS R35 HL135824
Abstract
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10
Indexed as
Aortic Valve StenosisCase-Control StudiesCoronary Artery DiseaseGenome-Wide Association StudyHumansPhenotypeRisk Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.