Evidence map›Paper›PMID 29511172›Full record

ArticleCell death & disease2018

Rb is required for retinal angiogenesis and lamination.

Yi Zhou, Ran Wei, Liu Zhang, Yongjiang Chen, Suying Lu, Chen Liang, Yujiao Wang, Lirong Xiao, Junjun Zhang, Rod Bremner and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Yi ZhouResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Ran WeiResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Liu ZhangLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Yongjiang ChenLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Suying LuLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Chen LiangResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yujiao WangResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Lirong XiaoResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Junjun ZhangDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Rod BremnerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. bremner@lunenfeld.ca.
Danian ChenResearch Laboratory of Ophthalmology and Vision Sciences, Torsten-Wiesel Research Institute of World Eye Organization, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. danianchen2006@qq.com.ORCID 0000-0002-6916-2978
Sichuan University · CNUniversity of Toronto · CALunenfeld-Tanenbaum Research Institute · CA

Funding

CIHR
6 · The paper itself

Abstract

Retinoblastoma tumor suppressor (Rb) promotes cell cycle exit, survival, differentiation, and tumor suppression in the retina. Here, we show it is also essential for vascularization and lamination. Despite minimal effects on Hif1a target expression, intraretinal vascular plexi did not form in the Rb

Indexed as

Neovascularization, PhysiologicAnimalsApoptosisCell CycleE2F2 Transcription FactorE2F3 Transcription FactorFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsRetinaRetinal VesselsRetinoblastoma ProteinE2F2 Transcription FactorE2F3 Transcription FactorRetinoblastoma Protein

Identifiers

PMID29511172
PMCPMC5840357
OpenAlexW2792497119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.