Evidence map›Paper›PMID 29511160›Full record

ArticleCell death & disease2018

MiR34 inhibition induces human heart progenitor proliferation.

Gioacchin Iannolo, Maria Rita Sciuto, Giuseppe Maria Raffa, Michele Pilato, Pier Giulio Conaldi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  8. Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Aging, MicroRNAs, and Heart Failure.Current problems in cardiology · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?Oxidative medicine and cellular longevity · 2019
    Review
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  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gioacchin IannoloDepartment of Laboratory Medicine and Advanced Biotechnologies, Regenerative Medicine and Biomedical Technologies Unit, IRCCS-ISMETT (Mediterranean Institute for Transplantation and advanced specialized Therapies), Palermo, Italy. iannolo@yahoo.com.
Maria Rita SciutoDepartment of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Giuseppe Maria RaffaDepartment for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Cardiac Surgery and Heart Transplantation Unit, IRCCS-ISMETT (Mediterranean Institute for Transplantation and advanced specialized Therapies), Palermo, Italy.
Michele PilatoDepartment for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Cardiac Surgery and Heart Transplantation Unit, IRCCS-ISMETT (Mediterranean Institute for Transplantation and advanced specialized Therapies), Palermo, Italy.
Pier Giulio ConaldiDepartment of Laboratory Medicine and Advanced Biotechnologies, Regenerative Medicine and Biomedical Technologies Unit, IRCCS-ISMETT (Mediterranean Institute for Transplantation and advanced specialized Therapies), Palermo, Italy.
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MiR34 involvement in myocardial injury repair and ageing has been well documented in mouse model. Our aim was to establish whether the inhibition of miR34 expression through locked nucleic acid (LNA) could be used as a pharmacological intervention to enhance human heart repair. Cardiac progenitor cells were obtained by right atrial specimen collection during intraoperative procedures. Our analysis revealed a direct correlation between miR34 expression and patient age, and its silencing by LNA promoted the cardiac progenitor growth rate up to twofold ( ± 0.8). Our results confirmed the relevance of miR34a in human heart ageing, as previously demonstrated in mouse. Moreover, the decrease of miR34 expression in the cardiac progenitor cell population indicates its role in maintaining an undifferentiated status and consequently in a lower proliferation rate with the involvement of genes such as Notch-1, Numb, and p63.

Indexed as

Cell ProliferationCell DifferentiationCells, CulturedHeartHumansMicroRNAsMyocardiumStem CellsMicroRNAsMIRN34 microRNA, human

Identifiers

PMID29511160
PMCPMC5840309
OpenAlexW2791161273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.