Evidence map›Paper›PMID 29511120›Full record

ArticleScience signaling2018

cAMPr: A single-wavelength fluorescent sensor for cyclic AMP.

Christopher R Hackley, Esteban O Mazzoni, Justin Blau

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 72 citations in OpenAlex.

  1. Chemical reviews · 2026
    Review
  2. Review
  3. Article
  4. Protein Engineering for Spatiotemporally Resolved Cellular Monitoring.Annual review of analytical chemistry (Palo Alto, Calif.) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Synthetic microbiology in sustainability applications.Nature reviews. Microbiology · 2024
    Review
  10. Use-Dependent, Untapped Dual Kinase Signaling Localized in Brain Learning Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Christopher R HackleyDepartment of Biology, New York University (NYU), 100 Washington Square East, New York, NY 10003, USA.ORCID 0000-0003-3955-8354
Esteban O MazzoniDepartment of Biology, New York University (NYU), 100 Washington Square East, New York, NY 10003, USA.ORCID 0000-0001-8994-681X
Justin BlauDepartment of Biology, New York University (NYU), 100 Washington Square East, New York, NY 10003, USA. justin.blau@nyu.edu.ORCID 0000-0001-9417-2716
New York University · USNew York University Abu Dhabi · AENYU Langone Health · US

Funding

Regulation of pacemaker neuronsR01GM063911 · NIGMS · NEW YORK UNIVERSITY · PI BLAU, JUSTIN · 2002 to 2019
$5.6M
Molecular mechanisms of direct neuronal programmingR01HD079682 · NICHD · NEW YORK UNIVERSITY · PI MAZZONI, ESTEBAN ORLANDO · 2014 to 2018
$1.5M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015518 · NCRR · NEW YORK UNIVERSITY · PI LENNIE, PETER · 2000 to 2000
$1.3M
NCRR NIH HHS C06 RR015518NICHD NIH HHS R01 HD079682NIGMS NIH HHS R01 GM063911
6 · The paper itself

Abstract

Genetically encoded fluorescent sensors enable cell-specific measurements of ions and small molecules in real time. Cyclic adenosine monophosphate (cAMP) is one of the most important signaling molecules in virtually all cell types and organisms. We describe cAMPr, a new single-wavelength cAMP sensor. We developed cAMPr in bacteria and embryonic stem cells and validated the sensor in mammalian neurons in vitro and in

Indexed as

AnimalsBacteriaBiosensing TechniquesBrainCalciumCells, CulturedCyclic AMPCyclic AMP-Dependent Protein KinasesDrosophilaEmbryonic Stem CellsFluorescence Resonance Energy TransferLuminescent ProteinsNeuronsTime-Lapse ImagingCalciumCyclic AMPCyclic AMP-Dependent Protein KinasesLuminescent Proteins

Identifiers

PMID29511120
PMCPMC5863242
OpenAlexW2791797416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.