Evidence map›Paper›PMID 29511025›Full record

ArticleG3 (Bethesda, Md.)2018

High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of

Lien D Bertier, Mily Ron, Heqiang Huo, Kent J Bradford, Anne B Britt, Richard W Michelmore

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Advances in CRISPR Plant Applications.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Substantial enhancement ofHorticulture research · 2025
    Article
  10. Integration of crop modeling and sensing into molecular breeding for nutritional quality and stress tolerance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Review
  11. Article
  12. Article
  13. An Improved Method forPlants (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lien D BertierGenome Center.
Mily RonDepartment of Plant Biology.
Heqiang HuoDepartment of Plant Sciences, Seed Biotechnology Center.
Kent J BradfordDepartment of Plant Sciences, Seed Biotechnology Center.
Anne B BrittDepartment of Plant Biology.
Richard W MichelmoreDepartments of Plant Sciences, Molecular & Cellular Biology, Medical Microbiology & Immunology, University of California, Davis, CA 95616 rwmichelmore@ucdavis.edu.
New York Genome Center · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable. To provide more insights into the efficiency of creating stable homozygous mutants using CRISPR/Cas9, we targeted

Indexed as

Gene EditingAllelesCRISPR-Cas SystemsGene Knockout TechniquesGenetic MarkersGerm CellsGerminationHot TemperatureInheritance PatternsLactucaMutationPhenotypePlant ProteinsPlants, Genetically ModifiedRNA, Guide, CRISPR-Cas SystemsSequence Analysis, DNAGenetic MarkersPlant ProteinsRNA, Guide, CRISPR-Cas Systemsamplicon sequencingCRISPR/Cas9germinationlettuceNHEJtargeted mutagenesisthermotolerance

Identifiers

PMID29511025
PMCPMC5940144
OpenAlexW2790826166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.