ArticleJournal of biomechanics2018
Masquelet technique: The effect of altering implant material and topography on membrane matrix composition, mechanical and barrier properties in a rat defect model.
Article in Journal of biomechanics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta-Analysis of Individual Participant Data.Orthopaedic surgery · 2023Pooled it
- Bone defect treatment: does the type and properties of the spacer affect the induction of Masquelet membrane? Evidence today.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Pooled it
- Co-Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap.Advanced healthcare materials · 2026Article
- 3D-Printed Bone Spacers with Dual-Phase Structure: A Comparison of Biogenic and Commercial Hydroxyapatite for Potential Treatment of Bone Defects.ACS applied bio materials · 2026Article
- Paracrine Influence of Masquelet's Induced Membrane on Marrow Derived Mesenchymal Stem Cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Review
- The Use of the Masquelet Technique in the Treatment of Pathological Distal Third Femoral Fracture Secondary to Chronic Osteomyelitis.Life (Basel, Switzerland) · 2025Article
- Engineering the bone reconstruction surgery: the case of the masquelet-induced membrane technique.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Construction of a 3D Degradable PLLA/β-TCP/CS Scaffold for Establishing an Induced Membrane Inspired by the Modified Single-Stage Masquelet Technique.ACS biomaterials science & engineering · 2025Article
- Multifunctional Bionic Periosteum with Ion Sustained-Release for Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biodegradable poly(caprolactone fumarate) 3D printed scaffolds for segmental bone defects within the Masquelet technique.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Unique Case of Accelerated Bone Growth Precipitating a One-Stage Masquelet: A Case Report.Journal of orthopaedic case reports · 2024Article
- Systematic literature review of in vivo rat femoral defect models using biomaterials to improve the induced membrane technique: a comprehensive analysis.EFORT open reviews · 2024Article
- Mechanical stimulation from the surrounding tissue activates mitochondrial energy metabolism in Drosophila differentiating germ cells.Developmental cell · 2023Article
- Reconstruction of a tibial diaphyseal bone defect using the Masquelet technique. A case report.Trauma case reports · 2022Article
- The induced membrane technique in animal models: a systematic review.OTA international : the open access journal of orthopaedic trauma · 2022Article
- Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Masquelet's induced membrane technique: Review of current concepts and future directions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Effects of topical mechanical stability on the formation of Masquelet membrane in a rabbit radial defect model.Scientific reports · 2020Article
- Introduction of a New Surgical Method to Improve Bone Healing in a Large Bone Defect by Replacement of the Induced Membrane by a Human Decellularized Dermis Repopulated with Bone Marrow Mononuclear Cells in Rat.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Masquelet technique is a surgical procedure to regenerate segmental bone defects. The two-phase treatment relies on the production of a vascularized foreign-body membrane to support bone grafts over three times larger than the traditional maximum. Historically, the procedure has always utilized a bone cement spacer to evoke membrane production. However, membrane formation can easily be effected by implant surface properties such as material and topology. This study sought to determine if the membrane's mechanical or barrier properties are affected by changing the spacer material to titanium or roughening the surface finish. Ten-week-old, male Sprague Dawley rats were given an externally stabilized, 6 mm femur defect which was filled with a pre-made spacer of bone cement (PMMA) or titanium (TI) with a smooth (∼1 μm) or roughened (∼8 μm) finish. After 4 weeks of implantation, the membranes were harvested, and the matrix composition, tensile mechanics, shrinkage, and barrier function was assessed. Roughening the spacers resulted in significantly more compliant membranes. TI spacers created membranes that inhibited solute transport more. There were no differences between groups in collagen or elastin distribution. This suggests that different membrane characteristics can be created by altering the spacer surface properties. Surgeons may unknowingly effecting membrane formation via bone cement preparation techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.