ArticleAlzheimer's research & therapy2018
The left frontal cortex supports reserve in aging by enhancing functional network efficiency.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.GeroScience · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Cognitive reserve and mild cognitive impairment in older adults of low socioeconomic status: evidence from an observational study in Colombia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Observational
- Integrating Network Pharmacology, Quantitative Metabolic Network Analysis,Combinatorial chemistry & high throughput screening · 2025Article
- Left Frontal Connectivity Moderates the Relationship between Inflammation and Cognitive Performance in Patients following Cardiac Surgery: A Longitudinal fMRI Study.Research (Washington, D.C.) · 2025Article
- Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer's disease.Alzheimer's research & therapy · 2024Article
- The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms.Molecular neurodegeneration · 2024Review
- Detecting cognitive decline in high-functioning older adults: The relationship between subjective cognitive concerns, frequency of high neuropsychological test scores, and the frontoparietal control network.Journal of the International Neuropsychological Society : JINS · 2024Article
- A measure of modifiable lifestyle factors shaping subjective cognitive reserve in the general population.Frontiers in psychology · 2024Article
- The Effect of Aging on Face-Name Recognition: An fMRI Study.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Article
- Detection of neurophysiological markers of cognitive reserve: an EEG study.Frontiers in aging neuroscience · 2024Article
- Neurophysiological markers in community-dwelling older adults with mild cognitive impairment: an EEG study.Alzheimer's research & therapy · 2023Article
- Proteomics analysis of prefrontal cortex of Alzheimer's disease patients revealed dysregulated proteins in the disease and novel proteins associated with amyloid-β pathology.Cellular and molecular life sciences : CMLS · 2023Article
- Interrelating differences in structural and functional connectivity in the older adult's brain.Human brain mapping · 2022Article
- Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading.Nature communications · 2022Article
- Prefrontal reactivity to TMS perturbation as a toy model of mental health outcomes during the COVID-19 pandemic.Heliyon · 2022Article
- TMS-Evoked Prefrontal Perturbation as a Toy Model of Brain Resilience to Stress During the COVID-19 Pandemic.Research square · 2021Article
- Human Brain Resilience: A Call to Action.Annals of neurology · 2021Review
- Effect of education on functional network edge efficiency in Alzheimer's disease.Scientific reports · 2021Article
- Cortical Networks Underpinning Compensation of Verbal Fluency in Normal Aging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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15 authors.
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Abstract
backgroundRecent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that global connectivity of a hub in the left frontal cortex (LFC connectivity) is associated with relatively preserved memory abilities and higher levels of protective factors (education, IQ) in normal aging and Alzheimer's disease. These results suggest that LFC connectivity supports reserve capacity, alleviating memory decline. An open question, however, is why LFC connectivity is beneficial and supports memory function in the face of neurodegeneration. We hypothesized that higher LFC connectivity is associated with enhanced efficiency in connected major networks involved in episodic memory. We further hypothesized that higher LFC-related network efficiency predicts higher memory abilities.
methodsWe assessed fMRI during a face-name association learning task performed by 26 healthy, cognitively normal elderly participants. Using beta-series correlation analysis, we computed task-related LFC connectivity to key memory networks, including the default mode network (DMN) and dorsal attention network (DAN). Network efficiency within the DMN and DAN was estimated by the graph theoretical small-worldness statistic. We applied linear regression analyses to test the association between LFC connectivity with the DMN/DAN and small-worldness of these networks. Mediation analysis was applied to test LFC connectivity to the DMN and DAN as a mediator of the association between education and higher DMN and DAN small-worldness. Last, we tested network small-worldness as a predictor of memory performance.
resultsWe found that higher LFC connectivity to the DMN and DAN during successful memory encoding and recognition was associated with higher small-worldness of those networks. Higher task-related LFC connectivity mediated the association between education and higher small-worldness in the DMN and DAN. Further, higher small-worldness of these networks predicted better performance in the memory task.
conclusionsThe present results suggest that higher education-related LFC connectivity to key memory networks during a memory task is associated with higher network efficiency and thus enhanced reserve of memory abilities in aging.
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