Evidence map›Paper›PMID 29510613›Full record

Trial reportCancer research and treatment2019

A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Moderately Emetogenic Chemotherapy: Results of the Korean South West Oncology Group (KSWOG) Study.

So-Yeon Jeon, Hye Sook Han, Woo Kyun Bae, Moo-Rim Park, Hyeok Shim, Sang-Cheol Lee, Se-Il Go, Hwan Jung Yun, Yong-Jin Im, Eun-Kee Song

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  3. Interventions for the prevention of acute phase chemotherapy-induced nausea and vomiting in adult and pediatric patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  13. Global inequitable distribution of seminal studies of chemotherapy-induced nausea and vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

So-Yeon JeonDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Hye Sook HanDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Woo Kyun BaeDepartment of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Moo-Rim ParkDepartment of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Hyeok ShimDepartment of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Sang-Cheol LeeDepartment of Internal Medicine, Soonchunhyang University Hospital, Cheonan, Korea.
Se-Il GoDepartment of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
Hwan Jung YunDepartment of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Yong-Jin ImCenter for Clinical Pharmacology and Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
Eun-Kee SongDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Jeonbuk National University Hospital · KRWonkwang University · KRChonnam National University Hwasun Hospital · KRChungbuk National University · KRChungnam National University · KRGyeongsang National University Hospital · KRJeonbuk National University · KRSoonchunhyang University Hospital Seoul · KR

Funding

Chonbuk National University Hospital
6 · The paper itself

Abstract

purposeData on the efficacy of olanzapine in patients receiving moderately emetogenic chemotherapy (MEC) are limited. This study aimed to evaluate and compare the efficacy of olanzapine versus placebo in controlling nausea and vomiting in patients receiving MEC. MATERIALS AND

methodsWe conducted a randomized, double-blind, placebo-controlled study to determine whether olanzapine can reduce the frequency of chemotherapy-induced nausea and vomiting (CINV) and improve the quality of life (QOL) in patients receiving palonosetron and dexamethasone as prophylaxis for MEC-induced nausea and vomiting. The primary end point was complete response for the acute phase (0-24 hours after chemotherapy). The secondary end points were complete response for the delayed (24-120 hours) and overall phase (0-120 hours), proportion of significant nausea (visual analogue scale ≥ 25 mm), use ofrescue medications, and effect on QOL.

resultsFifty-six patients were randomized to the olanzapine (n=29) and placebo (n=27) groups. Complete response rates were not significantly different between the olanzapine and placebo groups in the acute (96.5% vs. 88.0%, p=0.326), delayed (69.0% vs. 48.0%, p=0.118), and overall phases (69.0% vs. 48.0%, p=0.118). However, the percentage of patients with significant nausea (17.2% vs. 44.0%, p=0.032) and the use of rescue medications (0.03±0.19 vs. 1.88±2.88, p=0.002) were lower in the olanzapine group than in the placebo. Furthermore, the olanzapine group demonstrated better QOL (p=0.015).

conclusionOlanzapine combined with palonosetron and dexamethasone significantly improved QOL and vomiting control among previously untreated patients receiving MEC, although the efficacy was limited to the reduction of the frequency of CINV.

Indexed as

Administration, IntravenousAdultAgedAntineoplastic AgentsDexamethasoneDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansMaleMiddle AgedNauseaOlanzapinePalonosetronQuality of LifeAntineoplastic AgentsDexamethasoneOlanzapinePalonosetronAntiemeticsNauseaOlanzapineVomiting

Identifiers

PMID29510613
PMCPMC6333980
OpenAlexW2788267648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.