ArticleInternational journal of molecular sciences2018
Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene.
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Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Gene Mutations and Related Molecular Events in Distant Metastasis of Cervical Cancer: A Review.International journal of medical sciences · 2026Review
- Disrupting PDGFRA-driven immune evasion in glioma: vaccine-based strategies on the horizon.Frontiers in oncology · 2026Review
- Feasibility of Patient-Derived 3D Gastrointestinal Stromal Tumour Models as Alternatives for In Vivo Mouse Models.International journal of molecular sciences · 2025Article
- 18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors.JAMA network open · 2025Article
- Molecular Advances in the Treatment of Advanced Gastrointestinal Stromal Tumor.The oncologist · 2023Review
- Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers.Molecular cancer · 2023Review
- miRNA Expression May Have Implications for Immunotherapy in PDGFRA Mutant GISTs.International journal of molecular sciences · 2022Article
- The Management of Unresectable, Advanced Gastrointestinal Stromal Tumours.Targeted oncology · 2022Review
- A Robust Method for Sample Preparation of Gastrointestinal Stromal Tumour for LC/MS Untargeted Metabolomics.Metabolites · 2021Article
- Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.Signal transduction and targeted therapy · 2021Review
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- Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment.JCI insight · 2021Article
- Gastrointestinal Stromal Tumors (GISTs): Novel Therapeutic Strategies with Immunotherapy and Small Molecules.International journal of molecular sciences · 2021Review
- Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation.Frontiers in immunology · 2020Article
- Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report.World journal of clinical cases · 2019Article
- Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib.Scientific reports · 2019Article
- Somatic pharmacogenomics of gastrointestinal stromal tumor.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- BLU-285-the breakthrough in treatment of patients with aggressive systemic mastocytosis and gastrointestinal stromal tumor.Annals of translational medicine · 2018Article
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Authors and funding
18 authors at 4 institutions in 2 countries.
Valentina Indio"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. valentina.indio2@unibo.it.ORCID 0000-0002-8854-3821
Annalisa Astolfi"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. annalisa.astolfi@unibo.it.
Giuseppe Tarantino"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. giuseppe.tarantino6@unibo.it.ORCID 0000-0002-6078-6856
Milena Urbini"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. milena.urbini2@unibo.it.ORCID 0000-0002-3364-9098
Janice PattersonDivision of Hematology and Oncology, Portland VA Health Care System and OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. patterja@ohsu.edu.
Margherita NanniniDepartment of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. margherita.nannini@unibo.it.
Maristella SaponaraDepartment of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. maristella.saponara@unibo.it.
Lidia GattoDepartment of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. lidia.gatto83@gmail.com.
Donatella SantiniPathology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. donatella.santini@aosp.bo.it.
Italo F do ValleDepartment of Physics and Astronomy, L. Galvani Center for Biocomplexity, Biophysics and Systems Biology, University of Bologna, Bologna 40138, Italy.
Gastone CastellaniDepartment of Physics and Astronomy, L. Galvani Center for Biocomplexity, Biophysics and Systems Biology, University of Bologna, Bologna 40138, Italy. gastone.castellani@unibo.it.
Daniel RemondiniDepartment of Physics and Astronomy, L. Galvani Center for Biocomplexity, Biophysics and Systems Biology, University of Bologna, Bologna 40138, Italy. daniel.remondini@unibo.it.ORCID 0000-0003-3185-7456
Michelangelo FiorentinoLaboratory of Oncological and Transplant Molecular Pathology-Pathology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. michelangelo.fiorentino@aosp.bo.it.
Margaret von MehrenDepartment of Hematology and Medical Oncology, Fox Chase Cancer Center, Temple University Philadelphia, PA 19111, USA. margaret.vonmehren@fccc.edu.
Giovanni BrandiDepartment of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy. giovanni.brandi@unibo.it.
Guido Biasco"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. guido.biasco@unibo.it.
Michael C HeinrichDivision of Hematology and Oncology, Portland VA Health Care System and OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. heinrich@ohsu.edu.
Maria Aabbondanza Pantaleo"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna 40138 Italy. maria.pantaleo@unibo.it.
University of Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITOregon Health & Science University · USFox Chase Cancer Center · US
Funding
Regulation of oncogenic KIT by LMTK3I01BX000338 · VA · PORTLAND VA MEDICAL CENTER · PI HEINRICH, MICHAEL C · 2009 to 2019
–BLRD VA I01 BX000338
Abstract
Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha (
Indexed as
Mutation, MissenseTranscriptomeAdultAgedBenzimidazolesDrug Resistance, NeoplasmElectron Transport Complex IIF-Box-WD Repeat-Containing Protein 7FemaleGastrointestinal NeoplasmsGastrointestinal Stromal TumorsHumansImatinib MesylateIsocitrate DehydrogenaseMaleMiddle AgedBenzimidazolescrenolanibElectron Transport Complex IIF-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanIDH1 protein, humanImatinib MesylateIsocitrate DehydrogenasePiperidinesProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor alphaTumor Suppressor Protein p53crenolanibD842Vgastrointestinal stromal tumorsGISTKITPDGFRA
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