Evidence map›Paper›PMID 29510519›Full record

ArticleAntibiotics (Basel, Switzerland)2018

Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.

Diana Machado, João Perdigão, Isabel Portugal, Marco Pieroni, Pedro A Silva, Isabel Couto, Miguel Viveiros

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts.Journal of enzyme inhibition and medicinal chemistry · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance.Journal of clinical tuberculosis and other mycobacterial diseases · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Contribution of Efflux Pumps inAntibiotics (Basel, Switzerland) · 2019
    Article
  15. Article
  16. Article
  17. Fluoromycobacteriophages Can Detect ViableFrontiers in microbiology · 2018
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Diana MachadoGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisboa 1349-008, Portugal. diana@ihmt.unl.pt.ORCID 0000-0003-2375-2726
João PerdigãoiMed.ULisboa, Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa 1649-003, Portugal. jperdigao@ff.ulisboa.pt.
Isabel PortugaliMed.ULisboa, Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa 1649-003, Portugal. iportugal@ff.ulisboa.pt.
Marco PieroniP4T Group, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy. marco.pieroni@unipr.it.
Pedro A SilvaDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy. pedrefurg@gmail.com.
Isabel CoutoGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisboa 1349-008, Portugal. icouto@ihmt.unl.pt.
Miguel ViveirosGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisboa 1349-008, Portugal. mviveiros@ihmt.unl.pt.ORCID 0000-0001-9676-6251
Universidade Nova de Lisboa · PTUniversity of Lisbon · PTUniversidade Federal do Rio Grande · BRUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the growing body of knowledge on the contribution of efflux activity to

Indexed as

efflux inhibitorslineagesmutationsresistance levelstuberculosisverapamil

Identifiers

PMID29510519
PMCPMC5872129
OpenAlexW2789692141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.