Evidence map›Paper›PMID 29510494›Full record

ReviewMolecules (Basel, Switzerland)2018

Effects of the Usage of l-Cysteine (l-Cys) on Human Health.

Noelia Clemente Plaza, Manuel Reig García-Galbis, Rosa María Martínez-Espinosa

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Narrative Review of the Role of Nondepolarizing Neuromuscular Blocking Agents in Anesthesia: Perspective 2026.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Nettle (Food chemistry: X · 2025
    Article
  14. Article
  15. Synthesis,Future medicinal chemistry · 2025
    Article
  16. Review
  17. Review
  18. Fecal Microbiota Transplantation Activity ofFoods (Basel, Switzerland) · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noelia Clemente PlazaBiochemistry and Molecular Biology Division, Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, 03690 San Vicente del Raspeig, Spain. noelia_noseque@hotmail.com.
Manuel Reig García-GalbisDepartment of Nutrition and Dietetics, Faculty of Health Sciences, University of Atacama, Copiapó 2862, Chile. manuel.reig@uda.cl.ORCID 0000-0002-4428-0652
Rosa María Martínez-EspinosaBiochemistry and Molecular Biology Division, Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, 03690 San Vicente del Raspeig, Spain. rosa.martinezl@ua.es.ORCID 0000-0003-2679-135X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review summarizes recent knowledge about the use of the amino acid l-Cysteine (l-Cys) through diet, nutritional supplements or drugs with the aim to improve human health or treat certain diseases. Three databases (PubMed, Scopus, and Web of Science) and different keywords have been used to create a database of documents published between 1950 and 2017 in scientific journals in English or Spanish. A total of 60,885 primary publications were ultimately selected to compile accurate information about the use of l-Cys in medicine and nutritional therapies and to identify the reported benefits of l-Cys on human health. The number of publications about the use of l-Cys for these purposes has increased significantly during the last two decades. This increase seems to be closely related to the rise of nutraceutical industries and personalized medicine. The main evidence reporting benefits of l-Cys usage is summarized. However, the lack of accurate information and studies based on clinical trials hampers consensus among authors. Thus, the debate about the role and effectiveness of supplements/drugs containing l-Cys is still open.

Indexed as

Dietary SupplementsAlopeciaBibliometricsClinical Trials as TopicCysteineDiabetes Mellitus, Type 2DietFeeding BehaviorHumansPorphyria, ErythropoieticPrecision MedicineCysteinebiological medicinedietary supplements">l-cysteinenutraceuticalnutritional therapy

Identifiers

PMID29510494
PMCPMC6017824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.