ReviewInternational journal of molecular sciences2018
Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context.Frontiers in immunology · 2025Pooled it
- Moderate-high heritability and QTL associated with Manila clam Ruditapes philippinarum resistance to the parasite Perkinsus olseni.BMC genomics · 2026Article
- Antibiofilm Activity of Hemolymph Lectins from the Bivalve Mollusk Glycymeris yessoensis.Doklady. Biochemistry and biophysics · 2025Article
- Diversity of Toll-like Receptor Gene Transcripts in Hemocytes of Planorbarius corneus Mollusks (Gastropoda, Pulmonata) Uninfected and Infected with Bilharziella polonica.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025Article
- Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors.Marine drugs · 2024Review
- Article
- New l-Rhamnose-Binding Lectin from the BivalveMarine drugs · 2023Article
- 3D Optical Reconstruction of the Nervous System of the Whole-Body Marine Invertebrates.Chemical & biomedical imaging · 2023Article
- Invertebrate C1q Domain-Containing Proteins: Molecular Structure, Functional Properties and Biomedical Potential.Marine drugs · 2023Review
- Functional Diversity of Novel Lectins with Unique Structural Features in Marine Animals.Cells · 2023Review
- A C-type lectin in saliva of Aedes albopictus (Diptera: Culicidae) bind and agglutinate microorganisms with broad spectrum.Journal of insect science (Online) · 2023Article
- Article
- A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2023Article
- Immune diversity in lophotrochozoans, with a focus on recognition and effector systems.Computational and structural biotechnology journal · 2023Review
- Utilizing an artificial intelligence system to build the digital structural proteome of reef-building corals.GigaScience · 2022Article
- The Role of Anti-Viral Effector Molecules in Mollusc Hemolymph.Biomolecules · 2022Review
- Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.Chemical reviews · 2022Review
- Characterization of a C-Type Lectin Domain-Containing Protein with Antibacterial Activity from Pacific Abalone (International journal of molecular sciences · 2022Article
- Mollusc N-glycosylation: Structures, Functions and Perspectives.Biomolecules · 2021Review
- A Novel C1q Domain-Containing Protein Isolated from the MolluskMarine drugs · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-nonself discrimination is a common theme for all of the organisms in different evolutionary branches, which is also the most fundamental step for host immune protection. Plenty of pattern recognition receptors (PRRs) with great diversity have been identified from different organisms to recognize various pathogen-associated molecular patterns (PAMPs) in the last two decades, depicting a complicated scene of host-pathogen interaction. However, the detailed mechanism of the complicate PAMPs-PRRs interactions at the contacting interface between pathogens and hosts is still not well understood. All of the cells are coated by glycosylation complex and thick carbohydrates layer. The different polysaccharides in extracellular matrix of pathogen-host are important for nonself recognition of most organisms. Coincidentally, massive expansion of PRRs, majority of which contain recognition domains of Ig, leucine-rich repeat (LRR), C-type lectin (CTL), C1q and scavenger receptor (SR), have been annotated and identified in invertebrates by screening the available genomic sequence. The phylum Mollusca is one of the largest groups in the animal kingdom with abundant biodiversity providing plenty of solutions about pathogen recognition and immune protection, which might offer a suitable model to figure out the common rules of immune recognition mechanism. The present review summarizes the diverse PRRs and common elements of various PAMPs, especially focusing on the structural and functional characteristics of canonical carbohydrate recognition proteins and some novel proteins functioning in molluscan immune defense system, with the objective to provide new ideas about the immune recognition mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.