ArticleACS chemical biology2018
Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics.
Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Accelerating natural product discovery with linked MS-genomics and language/transformer-based models.npj antimicrobials and resistance · 2026Article
- Comparative genomics of the Streptomyces genus: insights into multi-stress-resistant genes for bioremediation.World journal of microbiology & biotechnology · 2025Article
- Integrated transcriptomic and metabolomic analysis reveals key genes and core metabolic pathways involved in phosphorus stress response in quinoa flower spikes.BMC plant biology · 2025Article
- Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products.Archives of pharmacal research · 2025Article
- Article
- Artificial intelligence for natural product drug discovery.Nature reviews. Drug discovery · 2023Review
- Integrated Metabolomic and Transcriptomic Analysis of the Quinoa Seedling Response to High Relative Humidity Stress.Biomolecules · 2023Article
- Biosynthetic gene profiling and genomic potential of the novel photosynthetic marine bacteriumFrontiers in microbiology · 2023Article
- Investigation of diverse biosynthetic secondary metabolites gene clusters using genome mining of indigenousIranian journal of microbiology · 2022Article
- Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus.Angewandte Chemie (International ed. in English) · 2022Article
- Chemometrics and genome mining reveal an unprecedented family of sugar acid-containing fungal nonribosomal cyclodepsipeptides.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transcriptomic and Metabolomic Analysis of the Response of Quinoa Seedlings to Low Temperatures.Biomolecules · 2022Article
- Comprehensive genome analysis of Lentzea reveals repertoire of polymer-degrading enzymes and bioactive compounds with clinical relevance.Scientific reports · 2022Article
- Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing.Microbiology spectrum · 2022Article
- Great diversity of KSFEMS microbes · 2022Article
- Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.Natural product reports · 2021Review
- Mining genomes to illuminate the specialized chemistry of life.Nature reviews. Genetics · 2021Review
- Thirtieth Anniversary of the Discovery of Laxaphycins. Intriguing Peptides Keeping a Part of Their Mystery.Marine drugs · 2021Review
- Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery.Nature communications · 2021Article
- Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
11 authors.
Funding
Abstract
Natural products (NPs) are a rich source of medicines, but traditional discovery methods are often unsuccessful due to high rates of rediscovery. Genetic approaches for NP discovery are promising, but progress has been slow due to the difficulty of identifying unique biosynthetic gene clusters (BGCs) and poor gene expression. We previously developed the metabologenomics method, which combines genomic and metabolomic data to discover new NPs and their BGCs. Here, we utilize metabologenomics in combination with molecular networking to discover a novel class of NPs, the tyrobetaines: nonribosomal peptides with an unusual trimethylammonium tyrosine residue. The BGC for this unusual class of compounds was identified using metabologenomics and computational structure prediction data. Heterologous expression confirmed the BGC and suggests an unusual mechanism for trimethylammonium formation. Overall, the discovery of the tyrobetaines shows the great potential of metabologenomics combined with molecular networking and computational structure prediction for identifying interesting biosynthetic reactions and novel NPs.
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