ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Serial Clustering of Late-Onset Group B Streptococcal Infections in the Neonatal Unit: A Genomic Re-evaluation of Causality.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.PLoS neglected tropical diseases · 2019Pooled it
- A single-center investigation on serotypes, drug resistance and clinical significance of GBS isolates from pregnant and non-pregnant adults in Baoji, China.Frontiers in cellular and infection microbiology · 2025Article
- Population genetics of group BFrontiers in microbiology · 2023Article
- Late-Onset Sepsis in a Premature Infant Mediated by Breast Milk: Mother-to-Infant Transmission of Group BInfection and drug resistance · 2022Article
- Article
- Understanding Factors in Group B Streptococcus Late-Onset Disease.Infection and drug resistance · 2021Review
- Whole-genome sequencing for neonatal intensive care unit outbreak investigations: Insights and lessons learned.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2021Article
- Enhanced Postnatal Acquisition of Hypervirulent Group B Streptococcus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Uncertainties in Screening and Prevention of Group B Streptococcus Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Genomic Insights Into the Distribution and Evolution of Group B Streptococcus.Frontiers in microbiology · 2019Review
- Transmission of Group B Streptococcus in late-onset neonatal disease: a narrative review of current evidence.Therapeutic advances in infectious diseaseReview
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
Background: Invasive Group B streptococcus (GBS) is a major cause of serious neonatal infection. Current strategies to reduce early-onset GBS disease have no impact on late-onset disease (LOD). Although GBS LOD is viewed as a sporadic event in the community, LOD arising within the neonatal intensive care unit (ICU) raises questions about mode of acquisition. Methods: Following a cluster of 4 GBS LOD cases, enhanced surveillance for all GBS LOD was undertaken over 2 years in the neonatal ICU supported by neonatal rectal screening. GBS isolates were serotyped and genome-sequenced. Results: Twelve late -onset invasive GBS episodes were identified (incidence 0.6/1000 live births). Genomic analysis revealed that 11/12 GBS isolates (92%) were linked to at least one other LOD isolate. Isolates from the first cluster were serotype V, resistant to macrolides and lincosamides, and sequencing confirmed isolates were indistinguishable, or distinguishable by only one SNP difference, from each other. Rectal carriage was rare. Prospective surveillance identified three further clusters of LOD due to serotypes Ia (3 cases), Ib (2 cases), and III (2 cases), that would not have been identified without surveillance and genome sequencing, leading to a re-evaluation of interventions required to prevent GBS LOD. Conclusion: Acquisition routes for LOD GBS in the neonatal ICU are poorly understood; cases may not necessarily be sporadic. Within this neonatal ICU, our data suggest that a single case of LOD GBS sepsis should be considered a potential nosocomial transmission event warranting prompt investigation, heightened infection prevention vigilance and action where required.
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