ArticlePloS one2018
Application of metabolomics in prediction of lymph node metastasis in papillary thyroid carcinoma.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Advances in postmortem interval estimation: A systematic review of machine learning and metabolomics across various tissue types.Forensic science, medicine, and pathology · 2025Pooled it
- Metabolite signature of human malignant thyroid tissue: A systematic review and meta-analysis.Cancer medicine · 2024Pooled it
- Trimethylamine N-oxide as a potential biomarker for predicting axillary lymph node metastasis in breast cancer: a retrospective study.World journal of surgical oncology · 2026Article
- Review
- hsa_circ_0101050 regulated by ZC3H13 enhances tumorigenesis in papillary thyroid cancer via mHeliyon · 2024Article
- Distinguishing benign and malignant thyroid nodules using plasma trimethylamine N-oxide, carnitine, choline and betaine.Journal of cancer research and clinical oncology · 2024Article
- Metabolomics-A Tool to Find Metabolism of Endocrine Cancer.Metabolites · 2022Review
- The potential value of LC-MS non-targeted metabonomics in the diagnosis of follicular thyroid carcinoma.Frontiers in oncology · 2022Article
- Risk factors for central lymph node metastasis in the cervical region in papillary thyroid carcinoma: a retrospective study.World journal of surgical oncology · 2021Article
- A glance at the actual role of glutamine metabolism in thyroid tumorigenesis.EXCLI journal · 2021Review
- The Potential of Metabolomics in the Diagnosis of Thyroid Cancer.International journal of molecular sciences · 2020Review
- Review
- Oncometabolites as biomarkers in thyroid cancer: a systematic review.Cancer management and research · 2019Review
- Metabolomics of thyroid nodules and the future.Archives of endocrinology and metabolism · 2018Article
- Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to find useful metabolites to predict lymph node (LN) metastasis in patients with papillary thyroid cancer (PTC) through a metabolomics approach and investigate the potential role of metabolites as a novel prognostic marker. MATERIALS AND
methodsFifty-two consecutive patients (median age: 41.5 years, range 15-74 years) were enrolled who underwent total thyroidectomy and central LN dissection with or without lateral LN dissection in Severance Hospital between October 2013 and July 2015. The study specimens were provided by the Severance Hospital Gene Bank, and consisted of PTC from each patient. The specimens were prepared for proton nuclear magnetic resonance (1H-NMR) spectroscopy. Spectral data by 1H-NMR spectroscopy were acquired, processed, and analyzed. Patients were grouped in three ways, according to the presence of LN metastasis, central LN metastasis and lateral LN metastasis. Chi-square test and the student t-test were used to analyze categorical variables and continuous variables, respectively. The Mann-Whitney U test was used for univariate analysis of metabolites. Orthogonal projections to latent structure discriminant analysis (OPLS-DA) was used for multivariate analysis to discriminate metabolic differences between the two groups.
resultsAmong 52 patients, 32 had central LN metastasis and 19 had lateral LN metastasis. No clinical or histopathological characteristic was significantly different for all comparisons. On univariate analysis, no metabolite showed significant difference for all comparisons. On multivariate analysis, OPLS-DA did not discriminate the presence and absence of LN metastasis. Lactate was found to be the most promising metabolite.
conclusionsNo metabolite could discriminate the presence of LN metastasis. However, lactate was found to be the most promising metabolite for discrimination. Further studies with larger sample sizes are needed to elucidate significant metabolites which can indicate the presence of LN metastasis in patients with PTC.
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