ArticleMenopause (New York, N.Y.)2018
25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve.
Article in Menopause (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the association between vitamin D and ovarian reserve.Scientific reports · 2021Pooled it
- The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Ovarian ageing: from biological constraint to emerging therapeutic frontier.Journal of assisted reproduction and genetics · 2026Review
- Inflammation and Ovarian Function in Reproductive-Aged Women.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Assessing vitamin D's impact on pregnancy success: a predictive model for assisted reproductive technology outcomes.Frontiers in reproductive health · 2025Article
- Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women.Fertility and sterility · 2024Article
- Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2023Article
- Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women.Scientific reports · 2022Article
- Seasonal dynamic of cholecalciferol (D3) and anti-Muellerian hormone (AMH) with impact on ovarian response and IVF/ICSI.Archives of gynecology and obstetrics · 2022Article
- Review
- FSH may mediate the association between HbA1c and bone turnover markers in postmenopausal women with type 2 diabetes.Journal of bone and mineral metabolism · 2022Article
- Review
- Ultraviolet radiation and age at natural menopause in a nationwide, prospective US cohort.Environmental research · 2022Article
- Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim of the study was to examine the associations between 25-hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve in a large community-based sample of women.
methodsIn 2010 to 2016, women aged 30 to 44 years without any known fertility problems were recruited from the Chapel Hill, NC area for a prospective time-to-pregnancy cohort study. At enrollment 561 women provided a blood sample that was used to measure 25(OH)D, anti-Müllerian hormone (AMH), follicle-stimulating hormone, and inhibin-B. Unadjusted associations were estimated with Spearman correlation coefficients. Multivariable linear regression was used to estimate associations of 25(OH)D with ovarian reserve biomarkers, after adjusting for age, race, body mass index, smoking history, and recent use of hormonal birth control.
resultsThe mean 25(OH)D was 36 ng/mL (SD = 11 ng/mL). 25(OH)D was not correlated with AMH, follicle-stimulating hormone, or inhibin-B (all r < 0.03). Multivariable results with continuous hormonal outcomes were also null. For dichotomous outcomes, there was a tendency for insufficient 25(OH)D (<30 ng/mL) to be associated with low AMH (<0.7 ng/mL) (odds ratio [95% CI]: 1.8 [0.9-4]).
conclusionsFor the most part, 25(OH)D was not associated with ovarian reserve biomarkers in a group of women trying to become pregnant. We found some evidence that low 25(OH)D (<30 ng/mL) was associated with low AMH, but this should be confirmed in studies with a higher prevalence of low 25(OH)D.
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