ArticleAmerican journal of respiratory and critical care medicine2018
Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.
Open access · greenAbstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 5 pooled it
34.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.Scientific reports · 2022Pooled it
- Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.Pediatric pulmonology · 2021Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Uncovering Outcome Disparities of βJournal of the National Medical Association · 2021Pooled it
- Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.Gastroenterology · 2019Pooled it
- Trial
- A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).Clinical pharmacology and therapeutics · 2019Trial
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- Treatment response and determinants of asthma control in Eastern Africa.BMC pulmonary medicine · 2026Article
- Multi-Ancestry Epigenome-Wide Meta-Analysis Identifies Novel Bulk and Cell-Type-Specific Epigenetic Markers of Asthma with Severe Exacerbations.medRxiv : the preprint server for health sciences · 2026Article
- Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL.American journal of human genetics · 2025Article
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Limited Proteolysis as a Regulator of Lymphatic Vessel Function and Architecture.International journal of molecular sciences · 2025Review
- Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
- Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025Review
- Article
- Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.Clinical epigenetics · 2023Article
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.Cell genomics · 2023Article
- Immunogenetics and pharmacogenetics of allergic asthma in Africa.Frontiers in allergy · 2023Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
54 authors at 20 institutions in 6 countries.
Angel C Y Mak1 Department of Medicine.ORCID 0000-0002-5372-4198
Marquitta J White1 Department of Medicine.
Walter L Eckalbar1 Department of Medicine.
Zachary A Szpiech2 Department of Bioengineering and Therapeutic Sciences.ORCID 0000-0001-6372-8224
Sam S Oh1 Department of Medicine.ORCID 0000-0002-2815-6037
Maria Pino-Yanes3 Research Unit, Hospital Universitario N. S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Donglei Hu1 Department of Medicine.
Pagé Goddard1 Department of Medicine.
Scott Huntsman1 Department of Medicine.
Joshua Galanter1 Department of Medicine.
Ann Chen Wu5 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Blanca E Himes7 Department of Biostatistics, Epidemiology and Informatics and.
Soren Germer8 New York Genome Center, New York, New York.
Julia M Vogel8 New York Genome Center, New York, New York.
Karen L Bunting8 New York Genome Center, New York, New York.
Celeste Eng1 Department of Medicine.
Sandra Salazar1 Department of Medicine.
Kevin L Keys1 Department of Medicine.
Jennifer Liberto1 Department of Medicine.
Thomas J Nuckton1 Department of Medicine.
Thomas A Nguyen1 Department of Medicine.
Dara G Torgerson9 Department of Pediatrics.
Pui-Yan Kwok10 Cardiovascular Research Institute.
Albert M Levin12 Department of Public Health Sciences.
Juan C Celedón13 Division of Pediatric Pulmonary Medicine, Allergy and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Erick Forno13 Division of Pediatric Pulmonary Medicine, Allergy and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-6497-9885
Hakon Hakonarson15 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Patrick M Sleiman15 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Amber Dahlin5 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Kelan G Tantisira5 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Scott T Weiss5 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Denise Serebrisky16 Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York.
Emerita Brigino-Buenaventura17 Department of Allergy and Immunology, Kaiser Permanente Vallejo Medical Center, Vallejo, California.
Harold J Farber18 Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.
Kelley Meade19 Children's Hospital and Research Center, Oakland, California.
Michael A Lenoir20 Bay Area Pediatrics, Oakland, California.
Pedro C Avila21 Department of Medicine, Northwestern University, Chicago, Illinois.
Saunak Sen1 Department of Medicine.
Shannon M Thyne22 Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
William Rodriguez-Cintron23 Veterans Caribbean Health Care System, San Juan, Puerto Rico.
Cheryl A Winkler24 Basic Science Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Frederick National Laboratory, Frederick, Maryland.
Andrés Moreno-Estrada25 National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico.
Karla Sandoval25 National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico.
Jose R Rodriguez-Santana26 Centro de Neumologia Pediatrica, San Juan, Puerto Rico.
Rajesh Kumar27 Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
L Keoki Williams29 Department of Internal Medicine, and.
Nadav Ahituv2 Department of Bioengineering and Therapeutic Sciences.
Elad Ziv1 Department of Medicine.
Max A Seibold31 Center for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, Colorado; and.
Robert B Darnell8 New York Genome Center, New York, New York.
Noah Zaitlen1 Department of Medicine.
Ryan D Hernandez2 Department of Bioengineering and Therapeutic Sciences.
Esteban G Burchard1 Department of Medicine.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Brigham and Women's Hospital · USNew York Genome Center · USCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXChildren's Hospital of Philadelphia · USNorthwestern University · USUniversity of Pittsburgh · USBaylor College of Medicine · USCardiovascular Institute Hospital · JPCentro de Neumologia Pediatrica · PRHenry Ford Health System · USHoward Hughes Medical Institute · USInstitute for Medical Informatics and Biostatistics · CHJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLeidos (United States) · USNational Jewish Health · USQB3 · USUniversidad de La Laguna · ESUniversity of California, Los Angeles · US
Funding
New York Center for Collaborative Research In Common Disease Genomics: Genome Aggregation and Joint Variant Calling for CCDG Freeze2UM1HG008901 · NHGRI · NEW YORK GENOME CENTER · PI MANIATIS, THOMAS P, WIGLER, MICHAEL H · 2016 to 2020
$56.6MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MUCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MThe Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MTranscriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI VOELKER, DENNIS R. · 2017 to 2021
$9.0MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MGenetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MMethods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MNCI NIH HHS R01 CA197139NHGRI NIH HHS R01 HG006399NHGRI NIH HHS U01 HG008684NHGRI NIH HHS UM1 HG008901NHLBI NIH HHS K01 HL130629NHLBI NIH HHS K01 HL140218NHLBI NIH HHS K08 HL125666NHLBI NIH HHS K25 HL121295NHLBI NIH HHS K99 HL135403NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL133433NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL138424NHLBI NIH HHS R37 HL066289NIAID NIH HHS R01 AI079139NICHD NIH HHS R01 HD085993NIDDK NIH HHS R01 DK113003NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS K12 GM081266NIGMS NIH HHS RL5 GM118984NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
Abstract
rationaleAlbuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.
objectivesTo identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children.
methodsWe performed the first whole-genome sequencing pharmacogenetics study from 1,441 children with asthma from the tails of the BDR distribution to identify genetic association with BDR. MEASUREMENTS AND MAIN
resultsWe identified population-specific and shared genetic variants associated with BDR, including genome-wide significant (P < 3.53 × 10
conclusionsThe lack of minority data, despite a collaboration of eight universities and 13 individual laboratories, highlights the urgent need for a dedicated national effort to prioritize diversity in research. Our study expands the understanding of pharmacogenetic analyses in racially/ethnically diverse populations and advances the foundation for precision medicine in at-risk and understudied minority populations.
Indexed as
Genome-Wide Association StudyRace FactorsAdolescentAlbuterolAsthmaBlack or African AmericanBronchodilator AgentsChildFemaleHispanic or LatinoHumansMaleMexican AmericansPharmacogenomic VariantsPolymorphism, Single NucleotideUnited StatesAlbuterolBronchodilator AgentsalbuterolasthmaLatinosminorityNFKB1
Identifiers
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