Evidence map›Paper›PMID 29509288›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Myeloid-derived suppressor cells increase and inhibit donor-reactive T cell responses to graft intestinal epithelium in intestinal transplant patients.

Shinji Okano, Kareem Abu-Elmagd, Danielle D Kish, Karen Keslar, William M Baldwin, Robert L Fairchild, Masato Fujiki, Ajai Khanna, Mohammed Osman, Guilherme Costa and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. LDLRJournal of clinical and translational hepatology · 2026
    Article
  3. Review
  4. Chimerism-Mediated Tolerance in Intestinal Transplantation.Gastroenterology clinics of North America · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Innate allorecognition in transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
  9. SpatiotemporalMolecular therapy. Methods & clinical development · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Shinji OkanoTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-8465-2898
Kareem Abu-ElmagdTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Danielle D KishDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Karen KeslarDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
William M BaldwinDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Robert L FairchildDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Masato FujikiTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Ajai KhannaTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-3330-0440
Mohammed OsmanTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Guilherme CostaTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
John FungTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Charles MillerTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Hiroto KayashimaTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Koji HashimotoTransplant Center, Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

POSTTRANSPLANT INFLAMMATORY RESPONSER01AI040459 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Robert L Fairchild · 1997 to 2026
$9.4M
NIAID NIH HHS R01 AI040459NIH HHS RO1-AI40459
6 · The paper itself

Abstract

Recent advances in immunosuppressive regimens have decreased acute cellular rejection (ACR) rates and improved intestinal and multivisceral transplant (ITx) recipient survival. We investigated the role of myeloid-derived suppressor cells (MDSCs) in ITx. We identified MDSCs as CD33

Indexed as

Cells, CulturedFollow-Up StudiesGraft RejectionGraft SurvivalHLA-DR AntigensHumansIntestinal MucosaIsoantibodiesLeukocytes, MononuclearMyeloid-Derived Suppressor CellsOrgan TransplantationPrognosisTissue DonorsT-LymphocytesHLA-DR AntigensIsoantibodiesclinical research/practiceimmune regulationimmunobiologyimmunosuppressant - steroidintestine/multivisceral transplantationrejection: acuterejection: T cell mediated (TCMR)T cell biology

Identifiers

PMID29509288
PMCPMC6127002
OpenAlexW2789520507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.