ArticleEpilepsia2018
Extrahippocampal high-frequency oscillations during epileptogenesis.
Article in Epilepsia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.Experimental neurology · 2026Article
- Kainic acid pig model of hippocampal epilepsy.Scientific reports · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Article
- Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid-induced rat epilepsy model.Experimental neurology · 2025Article
- Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography.Scientific reports · 2023Article
- Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy.Frontiers in neurology · 2023Article
- An approach for reliably identifying high-frequency oscillations and reducing false-positive detections.Epilepsia open · 2022Article
- Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?Epilepsia open · 2022Review
- Spike ripples in striatum correlate with seizure risk in two mouse models.Epilepsy & behavior reports · 2022Article
- Spatial and temporal profile of high-frequency oscillations in posttraumatic epileptogenesis.Neurobiology of disease · 2021Article
- Article
- Topographical reorganization of brain functional connectivity during an early period of epileptogenesis.Epilepsia · 2021Article
- Automatic Detection of High-Frequency Oscillations Based on an End-to-End Bi-Branch Neural Network and Clinical Cross-Validation.Computational intelligence and neuroscience · 2021Article
- Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis.Behavioural neurology · 2020Article
- Unit firing and oscillations at seizure onset in epileptic rodents.Neurobiology of disease · 2019Review
- Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice.Epilepsia open · 2019Article
- Expanding Brain-Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy.Frontiers in neuroscience · 2018Article
- Can EEG Abnormalities be a Biomarker of Epileptogenesis?Epilepsy currentsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The current study aimed to investigate the spatial and temporal patterns of high-frequency oscillations (HFOs) in the intra-/extrahippocampal areas during epileptogenesis. Local field potentials were bilaterally recorded from hippocampus (CA1), thalamus, motor cortex, and prefrontal cortex in 13 rats before and after intrahippocampal kainic acid (KA) lesions. HFOs in the ripple (100-200 Hz) and fast ripple (250-500 Hz) ranges were detected and their rates were computed during different time periods (1-5 weeks) after KA-induced status epilepticus (SE). Recurrent spontaneous seizures were observed in 7 rats after SE, and the other 6 rats did not develop epilepsy. During the latent period, the rate of hippocampal HFOs increased at the ipsilateral site of the KA lesion in both groups, and the HFO rate was significantly higher in the animals that later developed epilepsy. Animals that later developed epilepsy also demonstrated widespread appearance of HFOs, in both the ripple and the fast ripple range, whereas animals that did not develop epilepsy only exhibited changes in the ipsilateral intrahippocampal HFO rate. This study demonstrates an association between an increased rate of widespread HFOs and the later development of epilepsy, suggesting the formation of large-scale distributed pathological networks during epileptogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.