ArticleJournal of biomedical optics2018
Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Reflective broadband adaptive optics scanning light ophthalmoscope with 20 D focus range.Biomedical optics express · 2026Article
- DELETION INVOLVING EXON 18 OF RPGRIP1 IS a MAJOR CAUSE OF ACHROMATOPSIA.Retina (Philadelphia, Pa.) · 2026Observational
- In vivo imaging of the outer retina after an autologous neurosensory retinal free flap transplantation for a refractory macular hole closure.Journal of medical case reports · 2026Article
- ISOSNet: a unified framework for cone photoreceptor detection and inner segment and outer segment length measurement from AO-OCT B-scans.Biomedical optics express · 2025Article
- Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- Ultrafast adaptive optics for imaging the living human eye.Nature communications · 2024Article
- Foveal cone loss in tamoxifen maculopathy: a case report.Journal of medical case reports · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
- Programmable, high-speed, adaptive optics partially confocal multi-spot ophthalmoscope using a digital micromirror device.Optics letters · 2023Article
- Extracting spacing-derived estimates of rod density in healthy retinae.Biomedical optics express · 2023Article
- Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.Biomedical optics express · 2022Article
- Using deep learning for the automated identification of cone and rod photoreceptors from adaptive optics imaging of the human retina.Biomedical optics express · 2022Article
- Visible Light Optical Coherence Tomography Reveals the Relationship of the Myoid and Ellipsoid to Band 2 in Humans.Translational vision science & technology · 2022Article
- Artificial Intelligence Segmentation Algorithm-Based Optical Coherence Tomography Image in Evaluation of Binocular Retinopathy.Computational and mathematical methods in medicine · 2022Article
- Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging.Frontiers in aging neuroscience · 2022Review
- Cellular-Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography.Annual review of vision science · 2020Review
- Imaging Retinal Activity in the Living Eye.Annual review of vision science · 2019Review
- Coextensive synchronized SLO-OCT with adaptive optics for human retinal imaging.Optics letters · 2019Article
- Adaptive optics imaging of the human retina.Progress in retinal and eye research · 2019Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
We have designed and implemented a dual-mode adaptive optics (AO) imaging system that combines spectral domain optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) for in vivo imaging of the human retina. The system simultaneously acquires SLO frames and OCT B-scans at 60 Hz with an OCT volume acquisition time of 4.2 s. Transverse eye motion measured from the SLO is used to register the OCT B-scans to generate three-dimensional (3-D) volumes. Key optical design considerations include: minimizing system aberrations through the use of off-axis relay telescopes, conjugate pupil plane requirements, and the use of dichroic beam splitters to separate and recombine the OCT and SLO beams around the nonshared horizontal scanning mirrors. To demonstrate system performance, AO-OCT-SLO images and measurements are taken from three normal human subjects ranging in retinal eccentricity from the fovea out to 15-deg temporal and 20-deg superior. Also presented are en face OCT projections generated from the registered 3-D volumes. The ability to acquire high-resolution 3-D images of the human retina in the midperiphery and beyond has clinical importance in diseases, such as retinitis pigmentosa and cone-rod dystrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.