Evidence map›Paper›PMID 29508443›Full record

ArticleMagnetic resonance in medicine2018

Measurement of blood-brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging with reduced scan time.

Jonghyun Bae, Jin Zhang, Youssef Zaim Wadghiri, Atul Singh Minhas, Harish Poptani, Yulin Ge, Sungheon Gene Kim

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Extended perfusion protocol for MS lesion quantification.Open medicine (Warsaw, Poland) · 2020
    Article
  7. Feasibility of measuring blood-brain barrier permeability using ultra-short echo time radial magnetic resonance imaging.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonghyun BaeSackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, New York.
Jin ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, New York.
Youssef Zaim WadghiriBernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, New York.ORCID 0000-0001-7175-9397
Atul Singh MinhasCentre for Preclinical Imaging, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Harish PoptaniCentre for Preclinical Imaging, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Yulin GeBernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, New York.
Sungheon Gene KimBernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, New York.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
DCE MRI Study for Breast Cancer.R01CA160620 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIM, SUNGHEON GENE · 2012 to 2023
$5.4M
Medical Research Council MR/L012707/1NCI NIH HHS R01 CA160620NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

purposeTo investigate the feasibility of measuring the subtle disruption of blood-brain barrier (BBB) using DCE-MRI with a scan duration shorter than 10 min.

methodsThe extended Patlak-model (EPM) was introduced to include the effect of plasma flow (F

resultsThe simulation study results demonstrated that scan time reduction could lead to larger bias in PS estimated by PM (>2000%) than by EPM (<47%), especially when F

conclusionThe results of this study suggest that EPM can be used to measure PS with a scan duration of 10 min or less.

Indexed as

AnimalsBlood-Brain BarrierBrainBrain NeoplasmsCapillary PermeabilityComputer SimulationContrast MediaFemaleGlioblastomaImage Interpretation, Computer-AssistedMagnetic Resonance ImagingRatsTime FactorsContrast Mediablood-brain barrier (BBB)DCE-MRIextended Patlak modelPatlak modelpermeability

Identifiers

PMID29508443
PMCPMC6340058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.