ReviewWorld journal of pediatrics : WJP2018
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Review in World journal of pediatrics : WJP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- [Staphylococcal scalded skin syndrome: a pediatric dermatology emergency].Dermatologie (Heidelberg, Germany) · 2026Article
- Hospitalizations for staphylococcal scalded skin syndrome in Spain (2016-2023): unequal disease burden concentrated in infants.Frontiers in pediatrics · 2026Article
- Gene copy-number features generalize better than SNPs for antimicrobial resistance prediction in Staphylococcus aureus.npj antimicrobials and resistance · 2025Article
- Whole-genome sequencing and biofilm gene characterization in multidrug-Resistant Staphylococcus aureus clinical strains.Journal, genetic engineering & biotechnology · 2025Article
- Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential.Current issues in molecular biology · 2025Review
- Understanding host's response to staphylococcal scalded skin syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2025Review
- Identification of novel drug targets and small molecule discovery for MRSA infections.Frontiers in bioinformatics · 2025Article
- Staphylococcal Scalded Skin Syndrome in Melanated Skin: A Pediatric Case Report.HCA healthcare journal of medicine · 2025Article
- Case Report: Delayed recurrence of staphylococcal scalded skin syndrome in an extremely low birth weight infant.Frontiers in pediatrics · 2025Article
- Scaling and periorificial crusts in a pediatric patient.Infection · 2024Article
- Neonatal Severe Staphylococcal Scalded Skin Syndrome: Management with Autoadhesive Skin Substitute Dressing (SuprathelIndian journal of pediatrics · 2024Article
- The Clinical Characteristics and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2024Article
- Review
- Article
- Congenital staphylococcal scalded skin syndrome in a preterm infant.Clinical case reports · 2023Article
- Virulence Mechanisms of Staphylococcal Animal Pathogens.International journal of molecular sciences · 2023Review
- Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives.Nutrients · 2023Review
- Retrospective Study onAntibiotics (Basel, Switzerland) · 2023Article
- Recurrent staphylococcal scalded skin syndrome in a 20-month old-A case report.Clinical case reports · 2023Article
- Staphylococcal Infections and Neonatal Skin: Data from Literature and Suggestions for the Clinical Management from Four Challenging Patients.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcal-scalded skin syndrome (SSSS), also known as Ritter disease, is a potentially life-threatening disorder and a pediatric emergency. Early diagnosis and treatment is imperative to reduce the morbidity and mortality of this condition. The purpose of this article is to familiarize physicians with the evaluation, diagnosis, and treatment of SSSS. DATA SOURCES: A PubMed search was completed in Clinical Queries using the key terms "Staphylococcal scalded skin syndrome" and "Ritter disease".
resultsSSSS is caused by toxigenic strains of Staphylococcus aureus. Hydrolysis of the amino-terminal extracellular domain of desmoglein 1 by staphylococcal exfoliative toxins results in disruption of keratinocytes adhesion and cleavage within the stratum granulosum which leads to bulla formation. The diagnosis is mainly clinical, based on the findings of tender erythroderma, bullae, and desquamation with a scalded appearance especially in friction zones, periorificial scabs/crusting, positive Nikolsky sign, and absence of mucosal involvement. Prompt empiric treatment with intravenous anti-staphylococcal antibiotic such as nafcillin, oxacillin, or flucloxacillin is essential until cultures are available to guide therapy. Clarithromycin or cefuroxime may be used should the patient have penicillin allergy. If the patient is not improving, critically ill, or in communities where the prevalence of methicillin-resistant S. aureus is high, vancomycin should be used.
conclusionA high index of suspicion is essential for an accurate diagnosis to be made and treatment promptly initiated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.