Evidence map›Paper›PMID 29508263›Full record

ArticleMolecular imaging and biology2018

Tumor-Specific Zr-89 Immuno-PET Imaging in a Human Bladder Cancer Model.

Freddy E Escorcia, Jeffrey M Steckler, Dalya Abdel-Atti, Eric W Price, Sean D Carlin, Wolfgang W Scholz, Jason S Lewis, Jacob L Houghton

Open access · hybridAbstract read
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Immuno-PET Detects Changes in Multi-RTK Tumor Cell Expression Levels in Response to Targeted Kinase Inhibition.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  9. ImmunoPET Imaging of Pancreatic Tumors withMolecular imaging and biology · 2021
    Article
  10. Review
  11. Review
  12. PET/CT Imaging with anJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Freddy E EscorciaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Jeffrey M StecklerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Dalya Abdel-AttiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Eric W PriceWeill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA.
Sean D CarlinDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Wolfgang W ScholzMabVax Therapeutics, 11535 Sorrento Valley Rd, San Diego, California, 92121, USA.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Jacob L HoughtonDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. jacob.houghton@vanderbilt.edu.
Cornell University · USMemorial Sloan Kettering Cancer Center · USMabvax Therapeutics (United States) · USVanderbilt University Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Engineering HCC-selective PET agentZIABC011800 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ESCORCIA, FREDDY · 2018 to 2025
$10.6M
Molecular Imaging: Training for OncologyR25CA096945 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HRICAK, HEDVIG · 2002 to 2013
$5.2M
Characterization of human antibodies to sialyl-Lewis A (sLeA) derived from patienR42CA128362 · NCI · MABVAX THERAPEUTICS, INC. · PI SCHOLZ, WOLFGANG W · 2010 to 2011
$1.1M
Developing an Anti-sialyl-Lewisa Diabody for ImmunoPET Imaging of Pancreas CancerF32CA180452 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HOUGHTON, JACOB · 2014 to 2016
$122k
NCI NIH HHS F32 CA180452NCI NIH HHS HHSN261201300060CNCI NIH HHS P30 CA008748NCI NIH HHS R25 CA096945NCI NIH HHS R42 CA128362
6 · The paper itself

Abstract

purposeTumor-specific molecular imaging is an important tool for assessing disease burden and treatment response. CA19.9 is an important tumor-specific marker in several malignancies, including urothelial carcinoma. [ PROCEDURES: Surface expression of CA19.9 was confirmed in the human bladder cancer line HT 1197. The radioimmunoconjugate [

results[

conclusions[

Indexed as

Models, BiologicalPositron-Emission TomographyAnimalsAntibodies, MonoclonalAutoradiographyCA-19-9 AntigenCell Line, TumorHumansMice, NudeRadioisotopesSerumUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysZirconiumAntibodies, MonoclonalCA-19-9 AntigenRadioisotopesZirconiumZirconium-89AntibodyBladder cancerImmuno-PETMolecular imagingZirconium-89

Identifiers

PMID29508263
PMCPMC6153671
OpenAlexW2793335590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.