Evidence map›Paper›PMID 29508223›Full record

ArticleJournal of the American Society for Mass Spectrometry2018

Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments.

David J Harvey, Gemma E Seabright, Snezana Vasiljevic, Max Crispin, Weston B Struwe

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. In Silico Characterization of Glycan Ions from IM-MS Collision Cross Section.Journal of the American Society for Mass Spectrometry · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Identification ofThe Analyst · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Advancing Solutions to the Carbohydrate Sequencing Challenge.Journal of the American Chemical Society · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David J HarveyTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK. david.harvey@ndm.ox.ac.uk.
Gemma E SeabrightCenter for Biological Sciences, Faculty of Natural and Environmental Sciences, Life Sciences Building 85, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
Snezana VasiljevicDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Max CrispinCenter for Biological Sciences, Faculty of Natural and Environmental Sciences, Life Sciences Building 85, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
Weston B StruweDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. weston.struwe@chem.ox.ac.uk.
University of Southampton · GBUniversity of Oxford · GB

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
NIAID NIH HHS UM1 AI100663
6 · The paper itself

Abstract

Extracted arrival time distributions of negative ion CID-derived fragments produced prior to traveling-wave ion mobility separation were evaluated for their ability to provide structural information on N-linked glycans. Fragmentation of high-mannose glycans released from several glycoproteins, including those from viral sources, provided over 50 fragments, many of which gave unique collisional cross-sections and provided additional information used to assign structural isomers. For example, cross-ring fragments arising from cleavage of the reducing terminal GlcNAc residue on Man

Indexed as

AnimalsCarbohydrate SequenceGlycoproteinsIonsIsomerismMannoseMass SpectrometryPolysaccharidesGlycoproteinsIonsMannosePolysaccharidesCollision cross-sectionsFragment ionsHigh-mannose N-glycansIon mobilityTraveling wave

Identifiers

PMID29508223
PMCPMC5940726
OpenAlexW2790909261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.