Evidence map›Paper›PMID 29508191›Full record

ArticleJournal of molecular neuroscience : MN2018

Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia.

Anna L Kaysheva, Artur T Kopylov, Elena A Ponomarenko, Olga I Kiseleva, Nadezhda B Teryaeva, Alexander A Potapov, Alexander А Izotov, Sergei G Morozov, Valeria Yu Kudryavtseva, Alexander I Archakov

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna L KayshevaV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121. kaysheva1@gmail.com.ORCID http://orcid.org/0000-0003-4472-2016
Artur T KopylovV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121.
Elena A PonomarenkoV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121.
Olga I KiselevaV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121.
Nadezhda B TeryaevaN.-N. Burdenko Research Institute of Neurosurgery, Moscow, Russia.
Alexander A PotapovN.-N. Burdenko Research Institute of Neurosurgery, Moscow, Russia.
Alexander А IzotovV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121.
Sergei G MorozovInstitute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow, Russia.
Valeria Yu KudryavtsevaLtd. KuB, Moscow, Russia.
Alexander I ArchakovV.-N. Orekhovich Research Institute of Biomedical Chemistry, 10, Pogodinskaya St, Moscow, Russian Federation, 119121.

Funding

government assignment "Development of Mass-Spectrometry Test System for Identification of Biomarkers in the Blood Plasma, Allowed for Application in Clinical Diagnostics - Continuation" 0518-2015-0006
6 · The paper itself

Abstract

A comparative protein profile analysis of 17 blood plasma samples from patients with ischemia and 20 samples from healthy volunteers was carried out using ultra-high resolution mass spectrometry. The analysis of measurements was performed using the proteomics search engine OMSSA. Normalized spectrum abundance factor (NSAF) in the biological samples was assessed using SearchGUI. The findings of mass spectrometry analysis of the protein composition of blood plasma samples demonstrate that the depleted samples are quite similar in protein composition and relative abundance of proteins. By comparing them with the control samples, we have found a small group of 44 proteins characteristic of the blood plasma samples from patients with chronic cerebral ischemia. These proteins contribute to the processes of homeostasis maintenance, including innate immune response unfolding, the response of a body to stress, and contribution to the blood clotting cascade.

Indexed as

AdolescentAdultBiomarkersBrain IschemiaFemaleHumansMaleMiddle AgedProteomeBiomarkersProteomeChronic cerebral ischemiaLFQPanoramic mass spectrometryProtein markers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.