ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2018
Glutamate and Its Receptors as Therapeutic Targets for Migraine.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Approach to headache disorders and the management of migraine: consensus guidelines from the Headache Society of Singapore, first edition (2023).Singapore medical journal · 2026Guideline
- Role of memantine in adult migraine: a systematic review and network meta-analysis to compare memantine with existing migraine preventive medications.Frontiers in pharmacology · 2024Pooled it
- Trial
- Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial.The journal of headache and pain · 2021Trial
- Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Effects of sildenafil and calcitonin gene-related peptide on brainstem glutamate levels: a pharmacological proton magnetic resonance spectroscopy study at 3.0 T.The journal of headache and pain · 2018Trial
- Observational
- Pharmacological Modulation of the Kynurenine Pathway Using PF-04859989 Modulates PACAP Signaling in Migraine-Relevant Trigeminal Sensitization.Biomolecules · 2026Article
- Migraine and auditory dysfunction: beyond comorbidity.Journal of neurology · 2026Review
- Reduced thalamic glutathione in migraine: a MEGA-PRESS spectroscopy study.The journal of headache and pain · 2026Article
- In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Discovery of 7-(Pyridin-3-yl)thieno[3,2-ACS chemical neuroscience · 2026Article
- Clinical Phenotypes and Prognosis of Anti-mGluR1 Encephalitis: A Single-Center Case Series and Comprehensive Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Ro 64-6198, a selective NOP receptor agonist attenuates social impairments associated with NTG-induced migraine pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Production, Mechanisms, and Therapeutic Strategies of Tryptophan Metabolites in CNS Diseases.Molecular neurobiology · 2025Review
- Integrated ATAC-seq and RNA-seq analysis identifies Grid2 and Reln as potential regulatory genes in migraine pathophysiology.The journal of headache and pain · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Article
- Practical issues in the management of sleep, anxiety, and mood disorders in primary headaches.Arquivos de neuro-psiquiatria · 2025Review
- Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations.Neurobiology of disease · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is substantial evidence indicating a role for glutamate in migraine. Levels of glutamate are higher in the brain and possibly also in the peripheral circulation in migraine patients, particularly during attacks. Altered blood levels of kynurenines, endogenous modulators of glutamate receptors, have been reported in migraine patients. Population genetic studies implicate genes that are involved with glutamate signaling in migraine, and gene mutations responsible for familial hemiplegic migraine and other familial migraine syndromes may influence glutamate signaling. Animal studies indicate that glutamate plays a key role in pain transmission, central sensitization, and cortical spreading depression. Multiple therapies that target glutamate receptors including magnesium, topiramate, memantine, and ketamine have been reported to have efficacy in the treatment of migraine, although with the exception of topiramate, the evidence for the efficacy of these therapies is not strong. Also, because all of these therapies have other mechanisms of action, it is not possible to conclude that the efficacy of these drugs is entirely due to their effects on glutamate receptors. Further studies are needed to more clearly delineate the possible roles of glutamate and its specific receptor subtypes in migraine and to identify new ways of targeting glutamate for migraine therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.