Evidence map›Paper›PMID 29508130›Full record

ArticleHead and neck pathology2018

Head and Neck Kaposi Sarcoma: Clinicopathological Analysis of 11 Cases.

Abbas Agaimy, Sarina K Mueller, Thomas Harrer, Sebastian Bauer, Lester D R Thompson

Open access · bronzeAbstract read
In one paragraph

Article in Head and neck pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  6. Oral Manifestations Associated with HIV/AIDS Patients.Medicina (Kaunas, Lithuania) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Abbas AgaimyInstitute of Pathology, University Hospital, Krankenhausstrasse 8-10, 91054, Erlangen, Germany. abbas.agaimy@uk-erlangen.de.
Sarina K MuellerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital, 91054, Erlangen, Germany.
Thomas HarrerDepartment of Internal Medicine-3, University Hospital, 91054, Erlangen, Germany.
Sebastian BauerSarcoma Center, Western German Cancer Center, University of Duisburg-Essen Medical School, 45122, Essen, Germany.
Lester D R ThompsonDepartment of Pathology, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA, 91367, USA.
Universitätsklinikum Erlangen · DEUniversity of Duisburg-Essen · DEWoodland Hills Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kaposi sarcoma (KS) of the head and neck area is uncommon with limited published case series. Our routine and consultation files were reviewed for histologically and immunohistochemically proven KS affecting any cutaneous or mucosal head and neck site. Ten males and one female aged 42-78 years (median, 51 years; mean, 52 years) were retrieved. Eight patients were HIV-positive and three were HIV-negative. The affected sites were skin (n = 5), oral/oropharyngeal mucosa (n = 5), and lymph nodes (n = 3) in variable combination. The ear (pinna and external auditory canal) was affected in two cases; both were HIV-negative. Multifocal non-head and neck KS was reported in 50% of patients. At last follow-up (12-94 months; median, 46 months), most of patients were either KS-free (n = 8) or had ongoing remission under systemic maintenance therapy (n = 2). One patient was alive with KS (poor compliance). Histopathological evaluation showed classical features of KS. One case was predominantly sarcomatoid with prominent inflammation mimicking undifferentiated sarcoma. Immunohistochemistry showed consistent expression of CD31, CD34, ERG, D2-40 and HHV8 in all cases. This is one of the few series devoted to head and neck KS showing high prevalence of HIV-positivity, but also unusual presentations in HIV-negative patients with primary origin in the skin of the ear and the auditory canal. KS should be included in the differential diagnosis of difficult-to-classify spindle cell lesions at this uncommon location.

Indexed as

AdultAgedFemaleHead and Neck NeoplasmsHIV InfectionsHumansMaleMiddle AgedPrevalenceSarcoma, KaposiDifferential diagnosisEar canalHead and neckHHV8HIVImmunohistochemistryKaposi sarcomaOral cavity

Identifiers

PMID29508130
PMCPMC6232196
OpenAlexW2790849984

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.