ArticleIn vitro cellular & developmental biology. Animal2018
miR-152 regulates the proliferation and differentiation of C2C12 myoblasts by targeting E2F3.
Article in In vitro cellular & developmental biology. Animal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- A pathway analysis-based algorithm for calculating the participation degree of ncRNA in transcriptome.Scientific reports · 2022Article
- Long non-coding RNAEpigenetics · 2022Article
- MicroRNA-24-3p promotes skeletal muscle differentiation and regeneration by regulating HMGA1.Cellular and molecular life sciences : CMLS · 2022Article
- miR-152 Regulates Bovine Myoblast Proliferation by Targeting KLF6.Animals : an open access journal from MDPI · 2021Article
- ssc-miR-451 Regulates Porcine Primary Adipocyte Differentiation by Targeting ACACA.Animals : an open access journal from MDPI · 2020Article
- Downregulated miR-204 Promotes Skeletal Muscle Regeneration.BioMed research international · 2020Article
- MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice.International journal of molecular sciences · 2019Article
- Retracted Article: Long non-coding RNA TUG1 alleviates high glucose induced podocyte inflammation, fibrosis and apoptosis in diabetic nephropathyRSC advances · 2019Article
- Mir-152 Regulates 3T3-L1 Preadipocyte Proliferation and Differentiation.Molecules (Basel, Switzerland) · 2019Article
- MicroRNA-152 Promotes Slow-Twitch Myofiber Formation via Targeting Uncoupling Protein-3 Gene.Animals : an open access journal from MDPI · 2019Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
The development of skeletal muscle is a complex process involving the proliferation, differentiation, apoptosis, and changing of muscle fiber types in myoblasts. Many reports have described the involvement of microRNAs in the myogenesis of myoblasts. In this study, we found that the expression of miR-152 was gradually down-regulated during myoblast proliferation, but gradually up-regulated during the differentiation of myoblasts. Transfection with miR-152 mimics restrained cell proliferation and decreased the expression levels of cyclin E, CDK4, and cyclin D1, but promoted myotube formation and significantly increased the mRNA expression levels of MyHC, MyoD, MRF4, and MyoG in C2C12 myoblasts. However, treatment with miR-152 inhibitors promoted cell proliferation and restrained differentiation. Moreover, over-expression of miR-152 significantly decreased E2F3 production in C2C12 myoblasts. A luciferase assay confirmed that miR-152 could bind to the 3' UTR of E2F3. In conclusion, this study showed that miR-152 inhibited proliferation and promoted myoblast differentiation by targeting E2F3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.