ArticleClinical oral investigations2018
Investigation of clinicopathological parameters and expression of COX-2, bcl-2, PCNA, and p53 in primary and recurrent sporadic odontogenic keratocysts.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws.Journal of maxillofacial and oral surgery · 2024Article
- Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Discovery of metabolite biomarkers for odontogenic keratocysts.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts.International journal of oral science · 2024Article
- Appearance and recurrence of odontogenic keratocysts.Clinical and experimental dental research · 2023Article
- Various Surgical Interventions in Treating Odontogenic Keratocyst: A Radiological Case Report.Healthcare (Basel, Switzerland) · 2023Article
- Multiple odontogenic keratocysts in Ehlers-Danlos syndrome: a rare case report.BMC oral health · 2021Article
- Recurrence of odontogenic keratocysts and possible prognostic factors: Review of 455 patients.Medicina oral, patologia oral y cirugia bucal · 2019Article
- The concept of dysplasia in the lining of odontogenic keratocyst: A case report and review of the literature.Journal of oral and maxillofacial pathology : JOMFPArticle
- COX-2 expression and its correlation with cyst size in radicular cyst, dentigerous cyst, and odontogenic keratocyst: A comparative immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesOdontogenic keratocyst (OKC) presents considerable variation in aggressiveness and propensity for recurrence, yet hitherto, no explicit clinicopathological features have been determined to clearly demonstrate the potential for relapse. This retrospective study aims to investigate the prognostic relevance of various clinicopathological features as well as immunoexpression of COX-2, bcl-2, PCNA, and p53 in sporadic OKC. MATERIALS AND
methodsAmong 41 patients with OKC treated by enucleation, the frequency of recurrence for various clinicopathological features as well as immunoexpression for COX-2, bcl-2, PCNA, and p53 was evaluated.
resultsThe mean follow-up was 8.49 years, and recurrences were ascertained in 29.27% of cases. We found significant differences between recurrent and non-recurrent cysts in terms of multilocularity (P = 0.029), cortical perforation (P = 0.001), and lesion size (P < 0.001). Hazard risk for the recurrence was 3.362 (95% CI 1.066-10.598) for multilocular cysts, 7.801 (95% CI 2.1-28.985) for evidence of cortical perforation, and 1.004 (1.002-1.006) for 1 mm
conclusionsLarger size, multilocularity, and cortical perforation in sporadic OKC may be correlated with the relapse. CLINICAL RELEVANCE: Immunohistochemical analyses of COX-2, bcl-2, PCNA, and p53 lack prognostic utility in sporadic OKC.
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