Evidence map›Paper›PMID 29508103›Full record

ArticleAIDS and behavior2018

Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia.

Trena Mukherjee, Rishanantini Sakthivel, Ho Yen Fong, Megan McStea, Meng Li Chong, Sharifah Faridah Omar, Ai Vyrn Chin, Shahrul Kamaruzzaman, Adeeba Kamarulzaman, Reena Rajasuriar and 1 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Neurocognitive Complications of HIV Infection in Low-Income Countries.Current topics in behavioral neurosciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Trena MukherjeeDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Rishanantini SakthivelCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Ho Yen FongCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Megan McSteaCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Meng Li ChongCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Sharifah Faridah OmarCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Ai Vyrn ChinDepartment of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Shahrul KamaruzzamanDepartment of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Adeeba KamarulzamanCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia.
Reena RajasuriarCentre of Excellence for Research in AIDS (CERIA), University of Malaya, Kuala Lumpur, Malaysia. reena@um.edu.my.
Lucette A CysiqueNeuroscience Research Australia, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW, Australia.

Funding

Global HIV Implementation Science Research Training Grant RenewalT32AI114398 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Yael R Hirsch-Moverman · 2014 to 2026
$4.1M
National Institute of Allergy and Infectious Diseases T32AI114398NIAID NIH HHS T32 AI114398Universiti Malaya HIR/MOHE H-20001-E000001Universiti Malaya UM.0000099/HIRC3
6 · The paper itself

Abstract

This study determines the optimal cut-off scores for the Montreal Cognitive Assessment (MoCA) to detect HIV-associated neurocognitive disorders (HAND) in a multi-ethnic Malaysian HIV-positive cohort by developing demographically corrected normative standards among 283 HIV-negative community-based controls with overlapping demographic characteristics. The norms (corrected for age, sex, education, ethnicity) were applied to 342 HIV-positive virally suppressed individuals on cART. Impairment rates were classified using the Global Deficit Score (GDS ≥ .5) method. The MoCA was also scored according to the recommended cut-off of ≤ 26, and functional decline was applied to both impairment definitions to classify HAND per the Frascati criteria. The ≤ 26 cut-off considerably overestimated cognitive impairment in both samples (59.4% HIV-negative; 69.3% HIV-positive). In contrast, corrected scores yielded impairment rates consistent with what has been reported internationally in virally suppressed cohorts (23.4% with 83.3% mild impairment, 16.7% moderate impairment). A supplemental file allowing the computation of corrected MoCA scores and impairment status is included.

Indexed as

Neuropsychological TestsAgedAged, 80 and overCognitive DysfunctionCohort StudiesEthnicityExecutive FunctionFemaleHIV InfectionsHumansMalaysiaMaleMental Status and Dementia TestsMiddle AgedHandHIVMalaysiaMoCANormative values

Identifiers

PMID29508103
PMCPMC6123290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.