Evidence map›Paper›PMID 29507920›Full record

ArticleMetallomics : integrated biometal science2018

Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease.

Cheri M Ackerman, Peter K Weber, Tong Xiao, Bao Thai, Tiffani J Kuo, Emily Zhang, Jennifer Pett-Ridge, Christopher J Chang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metallomics : integrated biometal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

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  7. NanoSIP: NanoSIMS Applications for Microbial Biology.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cheri M AckermanDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu.ORCID 0000-0002-2683-2900
Peter K WeberNuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California, USA. weber21@llnl.gov pettridge2@llnl.gov.ORCID 0000-0001-6022-6050
Tong XiaoDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu and Howard Hughes Medical Institute, University of California, Berkeley, California, USA.ORCID 0000-0002-1780-5353
Bao ThaiDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu.
Tiffani J KuoDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu.
Emily ZhangDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu.
Jennifer Pett-RidgeNuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California, USA. weber21@llnl.gov pettridge2@llnl.gov.ORCID 0000-0002-4439-2398
Christopher J ChangDepartment of Chemistry, University of California, Berkeley, California, USA. chrischang@berkeley.edu and Howard Hughes Medical Institute, University of California, Berkeley, California, USA and Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA and Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.ORCID 0000-0001-5732-9497
Berkeley College · USHoward Hughes Medical Institute · USLawrence Livermore National Laboratory · US

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM079465NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

Copper is essential for eukaryotic life, and animals must acquire this nutrient through the diet and distribute it to cells and organelles for proper function of biological targets. Indeed, mutations in the central copper exporter ATP7A contribute to a spectrum of diseases, including Menkes disease, with symptoms ranging from neurodegeneration to lax connective tissue. As such, a better understanding of the fundamental impacts of ATP7A mutations on in vivo copper distributions is of relevance to those affected by these diseases. Here we combine metal imaging and optical imaging techniques at a variety of spatial resolutions to identify tissues and structures with altered copper levels in the Calamity

Indexed as

Disease Models, AnimalAnimalsCopperCopper-Transporting ATPasesLaser TherapyMenkes Kinky Hair SyndromeMitochondriaMultimodal ImagingMutationNanotechnologyPhenotypePhotoreceptor Cells, VertebrateSpectrometry, Mass, Electrospray IonizationSpectrometry, Mass, Secondary IonZebrafishCopperCopper-Transporting ATPases

Identifiers

PMID29507920
PMCPMC5864565
OpenAlexW2793136117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.