ArticleHepatology communications2018
New scoring classification for primary biliary cholangitis-autoimmune hepatitis overlap syndrome.
Article in Hepatology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis.Gut · 2025Guideline
- Austrian Society of Gastroenterology and Hepatology (ÖGGH) consensus on primary biliary cholangitis.Wiener klinische Wochenschrift · 2026Article
- Management of refractory autoimmune hepatitis with rituximab: a case series.Journal of medical case reports · 2025Article
- Article
- Overlap syndromes in autoimmune liver disease: a review.Translational gastroenterology and hepatology · 2025Review
- Challenges in the diagnosis and management of AIH-PBC syndrome.JHEP reports : innovation in hepatology · 2025Article
- Reply to: "Challenges in the diagnosis and management of AIH-PBC syndrome".JHEP reports : innovation in hepatology · 2025Article
- Diagnostic criteria and long-term outcomes in AIH-PBC variant syndrome under combination therapy.JHEP reports : innovation in hepatology · 2024Article
- Add-on immunosuppressive therapy may benefit selected patients with primary biliary cholangitis and autoimmune phenomena.Therapeutic advances in gastroenterology · 2024Article
- A nationwide study of autoimmune liver diseases in the Faroe Islands: Incidence, prevalence, and causes of death 2004 - 2021.International journal of circumpolar health · 2023Article
- Noninvasive diagnosis of AIH/PBC overlap syndrome based on prediction models.Open medicine (Warsaw, Poland) · 2022Article
- Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis.Pathologica · 2021Review
- Autoconversion of Autoimmune Liver Diseases.Digestive diseases and sciences · 2020Review
- [Clinicopathological analysis of anti-mitochondrial antibody negative primary biliary cholangitis-autoimmune hepatitis overlap syndrome].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019Article
- Overlap Syndrome and Myasthenia Gravis: An Uncommon Association With Unusual Features.ACG case reports journal · 2019Article
- Hellenic Association for the Study of the Liver (HASL): revised clinical practice guidelines for autoimmune hepatitis.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are two major immune-mediated chronic liver diseases. Overlap syndrome (OS) is diagnosed if patients have features of both AIH and PBC; however, there is no consensus on the definition or diagnostic criteria for OS. Here, we report a new scoring classification for OS and evaluate its usefulness. This new scoring classification was developed by modifying the International Autoimmune Hepatitis Group classification by selecting histologic features of AIH and PBC along with modifications of biochemical and immunologic characteristics. We evaluated 272 patients with chronic liver disease, including 105 with AIH, 102 with PBC, and 65 with OS. The best performance for the diagnosis of OS was noted among patients with an overlap score of ≥21 who had a sensitivity of 98.5%, a specificity of 92.8%, a positive predictive value of 81.0%, and a negative predictive value of 99.5%. By using a cut-off score of 21, 64 (98.5%) patients were diagnosed with OS as opposed to 9 (8.8%) and 6 (5.7%) with PBC and AIH, respectively. All patients with OS had an aggregate score of >19, whereas most patients with PBC or AIH scored <19, making this a safe discriminatory cut-off point against OS.
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Registered trials
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