Evidence map›Paper›PMID 29507666›Full record

ArticleOncotarget2018

High GSTP1 inhibits cell proliferation by reducing Akt phosphorylation and is associated with a better prognosis in hepatocellular carcinoma.

Xiaojia Liu, Ning Tan, Hongtao Liao, Guangdong Pan, Qing Xu, Rong Zhu, Liping Zou, Songqing He, Hongguang Zhu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xiaojia Liu *Department of Pathology, Basic Medical School, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Ning Tan *Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin 541001, China.
Hongtao LiaoLaboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin 541001, China.
Guangdong PanDepartment of Hepatobiliary Surgery, The People's Hospital of Liuzhou, Liuzhou 545001, China.
Qing XuLaboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin 541001, China.
Rong ZhuDepartment of Pathology, Basic Medical School, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Liping ZouDepartment of Pathology, Basic Medical School, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Songqing HeLaboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin 541001, China.
Hongguang ZhuDepartment of Pathology, Basic Medical School, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Guilin Medical University · CNFudan University · CNShanghai Medical College of Fudan University · CNLiuzhou General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutathione S-transferase (GST) family members promote carcinogenesis and cancer progression. We assessed GST pi 1 (GSTP1) mRNA and protein levels in hepatocellular carcinoma (HCC) using genome databases and tissue microarray (TMA) technology. We found that in cancerous tissues, GSTP1 mRNA was down-regulated in genome databases, and immunohistochemical staining of GSTP1 in 237 HCC cases varied from negative to strongly positive. GSTP1 levels correlated negatively with tumor size and serum alpha-fetoprotein (AFP) in HCC patients, and higher GSTP1 levels associated with longer overall survival (OS) and disease-free survival (DFS). We also found that GSTP1 overexpression restrained HepG2 and Huh7 liver cancer cell proliferation

Indexed as

Aktcell proliferationGSTP1hepatocellular carcinomaprognosis

Identifiers

PMID29507666
PMCPMC5823662
OpenAlexW2780537577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.