Evidence map›Paper›PMID 29507658›Full record

ArticleOncotarget2018

Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack.

Yoichi Yoshida, Hao Wang, Takaki Hiwasa, Toshio Machida, Eiichi Kobayashi, Seiichiro Mine, Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Hideyuki Kuroda and 15 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 2 countries.

Yoichi YoshidaDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hao WangDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takaki HiwasaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Toshio MachidaDepartment of Neurosurgery, Chiba Cerebral and Cardiovascular Center, Ichihara, Chiba, Japan.
Eiichi KobayashiDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Seiichiro MineDepartment of Neurosurgery, Chiba Cerebral and Cardiovascular Center, Ichihara, Chiba, Japan.
Go TomiyoshiDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Rika NakamuraDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Natsuko ShinmenDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hideyuki KurodaMedical Project Division, Research Development Center, Fujikura Kasei Co., Saitama, Japan.
Hirotaka TakizawaPort Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, Japan.
Koichi KashiwadoDepartment of Neurology, Kashiwado Hospital, Chiba, Japan.
Ikuo KamitsukasaDepartment of Neurology, Chiba Rosai Hospital, Chiba, Japan.
Hideo ShinDepartment of Neurosurgery, Higashi Funabashi Hospital, Chiba, Japan.
Takeshi WadaDepartment of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
Akiyo AotsukaDepartment of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
Eiichiro NishiDepartment of Pharmacology, Shiga University of Medical Science, Shiga, Japan.
Mikiko OhnoDepartment of Pharmacology, Shiga University of Medical Science, Shiga, Japan.
Minoru TakemotoDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Koutaro YokoteDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sho TakahashiClinical Research Center, Chiba University Hospital, Chiba, Japan.
Jun MatsushimaDepartment of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Xiao-Meng ZhangDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masaki TakiguchiDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yasuo IwadateDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Chiba University · JPFujikura (Japan) · JPChiba Aoba Municipal Hospital · JPChiba University Hospital · JPShiga University of Medical Science · JPChiba Cerebral and Cardiovascular Center · JPChiba Prefectural Sawara High School · JPChiba Rosai Hospital · JPFunabashi Orthopaedic Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease specific autoantibodies have been detected in the sera of patients with atherosclerosis-related diseases, such as cerebral infarction, cardiovascular disease. In the present study, we aimed to identify novel autoantibodies responsible for transient ischemic attack (TIA), a prodromal condition for cerebral infarction.

methodsTo identify candidate antigens, we screened a human aortic endothelial cell cDNA library using sera from 20 patients with TIA. Serum antibody levels were measured using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in 2 independent patient/healthy donor (HD) cohorts (

resultsFirst screening identified 3 candidate antigens. Of these, programmed cell death 11 (PDCD11) was determined to be associated with stroke (

conclusionSerum PDCD11-Ab level may serve as a potential biomarker for TIA.

Indexed as

autoantibodybiomarkercerebral infarctionGerotargetPDCD11TIA

Identifiers

PMID29507658
PMCPMC5823671
OpenAlexW2780301595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.