Evidence map›Paper›PMID 29507584›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2018

Clinical implications of CD4

Matthew Wiest, Katherine Upchurch, Wenjie Yin, Jerome Ellis, Yaming Xue, Bobby Lanier, Mark Millard, HyeMee Joo, SangKon Oh

Open access · goldAbstract read
In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Matthew Wiest *1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
Katherine Upchurch *1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
Wenjie Yin1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
Jerome Ellis1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
Yaming Xue1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
Bobby LanierTexas Allergy Experts, Fort Worth, TX USA.
Mark Millard4Martha Foster Lung Care Center, Baylor University Medical Center, Dallas, TX USA.
HyeMee Joo1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.
SangKon Oh1Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204 USA.ORCID 0000-0002-5546-1678
Baylor University · USBaylor University Medical Center · USTexas ENT and Allergy · US

Funding

Controlling Allergen-specific Th2-type Responses by Targeting DC Surface LectinsR21AI101810 · NIAID · BAYLOR RESEARCH INSTITUTE · PI OH, SANGKON · 2012 to 2013
$429k
NIAID NIH HHS R21 AI101810
6 · The paper itself

Abstract

backgroundT cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood.

methodsWe investigated the potential signatures of T cell subset phenotypes in asthma using fresh whole blood from adult atopic asthma patients (n = 43) and non-asthmatic control subjects (n = 22). We further assessed their potential clinical implications by correlating asthma severity.

resultsWe report four major features of CD4

conclusionsCCR4

Indexed as

Alpha 4AsthmaAtopicCCR4CCR7CD4+ T cellCorticosteroidCTLA-4IntegrinTherapyβ-Agonist

Identifiers

PMID29507584
PMCPMC5833086
OpenAlexW2791787824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.