ReviewThe journal of venomous animals and toxins including tropical diseases2018
Antivenom therapy: efficacy of premedication for the prevention of adverse reactions.
Review in The journal of venomous animals and toxins including tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Clinical study of anti-snake venom blockade in the treatment of local tissue necrosis caused by Chinese cobra (Naja atra) bites.PLoS neglected tropical diseases · 2022Trial
- Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom.Frontiers in immunology · 2021Trial
- Article
- Review
- A Nationwide Study on the Risks of Complications and Healthcare Costs of Snakebite Envenomation in Taiwan.The American journal of tropical medicine and hygiene · 2024Article
- The Chinese guideline for management of snakebites.World journal of emergency medicine · 2024Article
- Article
- Roughness of Production Conditions: Does It Really Affect Stability of IgG-Based Antivenoms?Toxins · 2022Article
- Article
- Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria.PLoS neglected tropical diseases · 2021Article
- Reports of Doses Administered and Adverse Reactions to Snake Antivenom Used in Uruguay in 2018.Frontiers in toxicology · 2021Article
- In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms.Toxins · 2020Article
- Article
- Article
- Snakebite: When the Human Touch Becomes a Bad Touch.Toxins · 2018Review
- Clinical and laboratory features distinguishing betweenThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Quality of horse F(ab')The journal of venomous animals and toxins including tropical diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antivenoms or antitoxins have been effectively used for more than a century. During this time, these products have always proven to be highly effective in the treatment of infections and envenomations. However, antivenoms did not exhibit good safety results in their initial applications. After many improvements, antivenoms have substantially better safety profiles but still have some side effects. Due to the occurrence of adverse reactions, the practice of using premedication with the intent to decrease side effects has become accepted or mandatory in many countries. The drugs used for premedication belong to the histamine H1 antagonist, glucocorticoid and catecholamine groups. Currently, this practice is being questioned due to low or controversial efficacies in clinical assays. In this article, we discuss the causes of adverse reactions, the mechanisms of drugs that block the undesired effects and the results obtained in clinical trials. Although these three families of drugs could have positive effects on reducing adverse reactions, only adrenaline has demonstrated positive results in clinical assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.