ArticleBiological procedures online2018
Silhouette Scores for Arbitrary Defined Groups in Gene Expression Data and Insights into Differential Expression Results.
Article in Biological procedures online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
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- Optimizing hybrid ensemble feature selection strategies for transcriptomic biomarker discovery in complex diseases.NAR genomics and bioinformatics · 2024Article
- Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling.Scientific reports · 2024Article
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- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- A review of model evaluation metrics for machine learning in genetics and genomics.Frontiers in bioinformatics · 2024Review
- The transcriptomic expression pattern of immune checkpoints shows heterogeneity between and within cancer types.American journal of cancer research · 2024Article
- Minor intron splicing is critical for survival of lethal prostate cancer.Molecular cell · 2023Article
- Rationale and performances of a data-driven method for computing the duration of pharmacological prescriptions using secondary data sources.Scientific reports · 2022Article
- Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources.European journal of clinical pharmacology · 2021Review
- Differential expression analysis using a model-based gene clustering algorithm for RNA-seq data.BMC bioinformatics · 2021Article
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- Prediction of severity and subtype of fibrosing disease using model informed by inflammation and extracellular matrix gene index.PloS one · 2020Article
- Activity-Dependent Remodeling of Synaptic Protein Organization Revealed by High Throughput Analysis of STED Nanoscopy Images.Frontiers in neural circuits · 2020Article
- Commentary: A Systematic Evaluation of Single Cell RNA-Seq Analysis Pipelines.Frontiers in genetics · 2020Article
- TCC-GUI: a Shiny-based application for differential expression analysis of RNA-Seq count data.BMC research notes · 2019Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHierarchical Sample clustering (HSC) is widely performed to examine associations within expression data obtained from microarrays and RNA sequencing (RNA-seq). Researchers have investigated the HSC results with several possible criteria for grouping (e.g., sex, age, and disease types). However, the evaluation of arbitrary defined groups still counts in subjective visual inspection.
resultsTo objectively evaluate the degree of separation between groups of interest in the HSC dendrogram, we propose to use
conclusionSilhouettes is useful for exploring data with predefined group labels. It would help provide both an objective evaluation of HSC dendrograms and insights into the DE results with regard to the compared groups.
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