Evidence map›Paper›PMID 29507407›Full record

ReviewNature neuroscience2018

Promises and limitations of human intracranial electroencephalography.

Josef Parvizi, Sabine Kastner

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04748146 (CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVAL), which is not on this map. Cited by 305 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 4 pooled it
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04748146 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Causal mechanisms of distributed brain network function during episodic memory retrieval

TypeinterventionalSponsorNorthwestern UniversityRan2026 to 2027Enrolled0ConditionsEpisodic MemoryArmsBrain stimulation
3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 4 syntheses or guidelines pooled it, 640 citations in OpenAlex.

  1. Pooled it
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  13. A single cortical circuit implements fast and slow visual search.bioRxiv : the preprint server for biology · 2026
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245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Josef ParviziLaboratory of Behavioral & Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP), Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA. parvizi@stanford.edu.
Sabine KastnerDepartment of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Princeton University · USStanford University · US

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI STEPHANIE Ruggiano JONES · 2017 to 2026
$25.3M
Functions of the Thalamus in Perception and CognitionR01EY017699 · NEI · PRINCETON UNIVERSITY · PI SABINE KASTNER · 2007 to 2026
$6.4M
Neural mechanisms of attentionR01MH064043 · NIMH · PRINCETON UNIVERSITY · PI KASTNER, SABINE, KNIGHT, ROBERT THOMAS · 2002 to 2020
$5.2M
Numbers in the Human BrainR01MH109954 · NIMH · STANFORD UNIVERSITY · PI PARVIZI, JOSEF · 2016 to 2020
$2.0M
Memory, Attention, and Default Mode Processes in Human Posteromedial CortexR01NS078396 · NINDS · STANFORD UNIVERSITY · PI PARVIZI, JOSEF · 2012 to 2016
$1.7M
NEI NIH HHS R01 EY017699NIMH NIH HHS P50 MH109429NIMH NIH HHS R01 MH064043NIMH NIH HHS R01 MH109954NINDS NIH HHS R01 NS078396
6 · The paper itself

Abstract

Intracranial electroencephalography (iEEG), also known as electrocorticography when using subdural grid electrodes or stereotactic EEG when using depth electrodes, is blossoming in various fields of human neuroscience. In this article, we highlight the potentials of iEEG in exploring functions of the human brain while also considering its limitations. The iEEG signal provides anatomically precise information about the selective engagement of neuronal populations at the millimeter scale and the temporal dynamics of their engagement at the millisecond scale. If several nodes of a given network are monitored simultaneously with implanted electrodes, the iEEG signals can also reveal information about functional interactions within and across networks during different stages of neural computation. As such, human iEEG can complement other methods of neuroscience beyond simply replicating what is already known, or can be known, from noninvasive lines of research in humans or from invasive recordings in nonhuman mammalian brains.

Indexed as

Brain MappingAnimalsBrainBrain WavesElectrodes, ImplantedElectroencephalographyHumansModels, NeurologicalNeurons

Identifiers

PMID29507407
PMCPMC6476542
OpenAlexW2790682483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.