ArticleScientific reports2018
Genetic profiling of poorly differentiated sinonasal tumours.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review.Frontiers in immunology · 2025Review
- Update on olfactory neuroblastoma.Virchows Archiv : an international journal of pathology · 2024Review
- Sox2 and βIII-Tubulin as Biomarkers of Drug Resistance in Poorly Differentiated Sinonasal Carcinomas.Journal of personalized medicine · 2023Article
- Genomic profiling and immune landscape of olfactory neuroblastoma in China.Frontiers in oncology · 2023Article
- Poorly differentiated sinonasal neuroendocrine carcinoma with skull base invasion: A case report.Surgical neurology international · 2023Article
- DNA methylation-based classification of sinonasal tumors.Nature communications · 2022Article
- Biomarkers for Immunotherapy in Poorly Differentiated Sinonasal Tumors.Biomedicines · 2022Article
- The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours.Advances in therapy · 2022Review
- Article
- Methylation Drivers and Prognostic Implications in Sinonasal Poorly Differentiated Carcinomas.Cancers · 2021Article
- The genomics and epigenetics of olfactory neuroblastoma: A systematic review.Laryngoscope investigative otolaryngology · 2021Review
- Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.Current oncology reports · 2020Review
- Sinonasal Undifferentiated Carcinoma.Current oncology reports · 2019Review
- Skin Biopsy in the Diagnosis of a Rare Case of Sinonasal Undifferentiated Carcinoma.Indian journal of dermatologyArticle
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The sinonasal cavities harbour a variety of rare tumour types. Many carry a poor prognosis while therapeutic options are limited. Histopathological classification can be difficult, especially for poorly differentiated tumours such as olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC). We analysed Affymetrix OncoScan genome-wide copy number profiles of these three tumour types, both as originally diagnosed and as regrouped by their cytokeratin (Ck) and neuroendocrine (Ne) expression pattern, aiming to find a relation between phenotype and genotype. According to the original histopathological classification our series consisted of 24 ONB, 11 SNEC and 19 SNUC, while immunohistochemistry indicated 11 Ck-Ne+/ONB, 18 Ck+Ne+/SNEC, 24 Ck+Ne-/SNUC, and 1 Ck-Ne-/unclassified. As originally diagnosed, the three tumour types showed similar copy number profiles. However, when regrouped by Ck/Ne immunostaining we found a distinct set of gains and losses; Ck-Ne+/ONB harboured few and predominantly whole chromosomes abnormalities, Ck+Ne+/SNEC carried both gains and losses in high frequency, and Ck+Ne-/SNUC showed mostly gains. In addition, each tumour carried a number of unique chromosomal deletions. Genome-wide copy number profiling supports the value of immunohistochemical CkNe staining of ONB, SNEC and SNUC for tumour classification, which is important for prognosis and therapeutic decision-making.
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