ArticleMolecular psychiatry2019
Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior.
Article in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.Molecular psychiatry · 2026Article
- High-Phenolic Cocoa Enhances Drug-Induced Reinstatement of Cocaine-Conditioned Place Preference Independently of Increasing Adult Hippocampal Neurogenesis.Food science & nutrition · 2025Article
- The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats.Psychopharmacology · 2024Article
- Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal.Research square · 2023Article
- Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal.bioRxiv : the preprint server for biology · 2023Article
- Progenitor Cells Play a Role in Reinstatement of Ethanol Seeking in Adult Male and Female Ethanol Dependent Rats.International journal of molecular sciences · 2023Article
- Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: A potential role of adult hippocampal neurogenesis in "curiosity".The Journal of comparative neurology · 2023Article
- Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits.Molecular psychiatry · 2021Article
- Hippocampal neurogenesis promotes preference for future rewards.Molecular psychiatry · 2021Article
- 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration.Journal of clinical medicine · 2021Article
- Circuit selectivity in drug versus natural reward seeking behaviors.Journal of neurochemistry · 2021Review
- Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders.Frontiers in pharmacology · 2021Review
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
- Indices of dentate gyrus neurogenesis are unaffected immediately after or following withdrawal from morphine self-administration compared to saline self-administering control male rats.Behavioural brain research · 2020Article
- The Pro-neurogenic Effects of Cannabidiol and Its Potential Therapeutic Implications in Psychiatric Disorders.Frontiers in behavioral neuroscience · 2020Review
- Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for Addictive Disorders.Cell transplantationReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.