ArticleScientific reports2018
Cedratvirus getuliensis replication cycle: an in-depth morphological analysis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Infection cycles of viruses of the phylum Nucleocytoviricota.Nature reviews. Microbiology · 2026Review
- The final cut: how giant viruses of protists are released from their hosts' cells.Archives of virology · 2025Review
- Giant viruses inhibit superinfection by downregulating phagocytosis inJournal of virology · 2024Article
- A long-term prospecting study on giant viruses in terrestrial and marine Brazilian biomes.Virology journal · 2024Article
- The consequences of viral infection on protists.Communications biology · 2024Review
- Cytopathic effects in Mimivirus infection: understanding the kinetics of virus-cell interaction.Memorias do Instituto Oswaldo Cruz · 2024Article
- Pithoviruses Are Invaded by Repeats That Contribute to Their Evolution and Divergence from Cedratviruses.Molecular biology and evolution · 2023Article
- Surface fibrils on the particles of nucleocytoviruses: A review.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.FEMS microbiology reviews · 2023Article
- Analysis of the Genomic Features and Evolutionary History of Pithovirus-Like Isolates Reveals Two Major Divergent Groups of Viruses.Journal of virology · 2023Article
- Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors.Traffic (Copenhagen, Denmark) · 2022Article
- Review
- RNA Sequencing of Medusavirus Suggests Remodeling of the Host Nuclear Environment at an Early Infection Stage.Microbiology spectrum · 2021Article
- Quantitative conversion of biomass in giant DNA virus infection.Scientific reports · 2021Article
- Morphological and Genomic Features of the New Klosneuvirinae Isolate Fadolivirus IHUMI-VV54.Frontiers in microbiology · 2021Article
- Yaravirus: A novel 80-nm virus infectingProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Evolution of a major virion protein of the giant pandoraviruses from an inactivated bacterial glycoside hydrolase.Virus evolution · 2020Article
- Virus goes viral: an educational kit for virology classes.Virology journal · 2020Article
- In-depth analysis of the replication cycle of Orpheovirus.Virology journal · 2019Article
- Giant virus vs amoeba: fight for supremacy.Virology journal · 2019Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The giant viruses are the largest and most complex viruses in the virosphere. In the last decade, new members have constantly been added to this group. Here, we provide an in-depth descriptive analysis of the replication cycle of Cedratvirus getuliensis, one of the largest viruses known to date. We tracked the virion entry, the early steps of virus factory and particles morphogenesis, and during this phase, we observed a complex and unique sequential organization of immature particle elements, including horseshoe and rectangular compartments, revealed by transverse and longitudinal sections, respectively, until the formation of the final ovoid-shaped striped virion. The genome and virion proteins are incorporated through a longitudinal opening in the immature virion, followed by the incorporation of the second cork and thickening of the capsid well. Moreover, many cell modifications occur during viral infection, including intense membrane trafficking important to viral morphogenesis and release, as evidenced by treatment using brefeldin A. Finally, we observed that Cedratvirus getuliensis particles are released after cellular lysis, although we obtained microscopic evidence that some particles are released by exocytosis. The present study provides new information on the unexplored steps in the life cycle of cedratviruses.
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