Evidence map›Paper›PMID 29507327›Full record

ArticleScientific reports2018

Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.

Jianqiang Yang, Ning Yi, Junhui Zhang, Wen He, Di He, Wanwan Wu, Shuyang Xu, Feng Li, Guoping Fan, Xianmin Zhu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. IntegrativeNutrients · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. TheFrontiers in endocrinology · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jianqiang YangDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
Ning YiTranslational Center for Stem Cell Research, Tongji Hospital, Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, 200065, China.
Junhui ZhangTranslational Center for Stem Cell Research, Tongji Hospital, Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, 200065, China.
Wen HeTranslational Center for Stem Cell Research, Tongji Hospital, Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, 200065, China.
Di HeShanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200433, China.
Wanwan WuShanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200433, China.
Shuyang XuShanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200433, China.
Feng LiShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Guoping FanDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5235-6410
Xianmin ZhuShanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200433, China. xianminzhu@hotmail.com.
Zhigang XueTranslational Center for Stem Cell Research, Tongji Hospital, Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, 200065, China. xuezg@tongji.edu.cn.
Wensheng ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China. zhouwesh@163.com.
Tongji University · CNNanchang University · CNShanghai Public Health Clinical Center · CNUniversity of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Thyroid stimulating hormone receptor (TSHR), a G-protein-coupled receptor, is important for thyroid development and growth. In several cases, frameshift and/or nonsense mutations in TSHR were found in the patients with congenital hypothyroidism (CH), however they have not been functionally studied in an animal model. In the present work, we generated a unique Tshr

Indexed as

Disease Models, AnimalAnimalsBody WeightCongenital HypothyroidismCRISPR-Cas SystemsGene Knockdown TechniquesMutationRatsRats, Sprague-DawleyReceptors, ThyrotropinThymus GlandThyroid HormonesReceptors, ThyrotropinThyroid Hormones

Identifiers

PMID29507327
PMCPMC5838214
OpenAlexW2792313344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.