ArticleScientific reports2018
A retrospective study of community-acquired Clostridium difficile infection in southwest China.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The prevalence and molecular epidemiology ofEmerging microbes & infections · 2026Observational
- From colonization to infection: Genomic evolution of Clostridioides difficile pathogenesis.Cell reports · 2026Review
- Ecological and dietary strategies to constrain Clostridioides difficile.Cell host & microbe · 2026Review
- Comparative genomic analysis ofMicrobial genomics · 2026Article
- Article
- Clinical and molecular epidemiology ofFrontiers in microbiology · 2026Article
- Dual Fluorescent Labeling for Bacterial Aggregation Assays.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Isolating C. difficile from Animal Samples.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Changing patterns and biological features of community-acquiredMicrobiology spectrum · 2025Article
- Community-AcquiredInternational journal of molecular sciences · 2025Review
- Abundant geographical divergence of Clostridioides difficile infection in China: a prospective multicenter cross-sectional study.BMC infectious diseases · 2025Article
- Genomic epidemiology ofEmerging microbes & infections · 2024Article
- Development and evaluation of a rapid visual loop-mediated isothermal amplification assay for thePeerJ · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Analysis of risk factors for community-acquiredTranslational pediatrics · 2023Article
- An epidemiological surveillance study (2021-2022): detection of a high diversity of Clostridioides difficile isolates in one tertiary hospital in Chongqing, Southwest China.BMC infectious diseases · 2023Article
- Antibiotic resistance and genomic features ofPeerJ · 2022Article
- An Atypical Case of MonomicrobialFrontiers in cellular and infection microbiology · 2022Article
- Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong.Emerging infectious diseases · 2021Article
- Response of the gut microbiota during the Clostridioides difficile infection in tree shrews mimics those in humans.BMC microbiology · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify the prevalence and characteristics of community-acquired Clostridium difficile infection (CA-CDI) in southwest China, we conducted a cross-sectional study. 978 diarrhea patients were enrolled and stool specimens' DNA was screened for virulence genes. Bacterial culture was performed and isolates were characterized by PCR ribotyping and multilocus sequence typing. Toxin genes tcdA and/or tcdB were found in 138/978 (14.11%) cases for fecal samples. A total of 55 C. difficile strains were isolated (5.62%). The positive rate of toxin genes and isolation results had no statistical significance between children and adults groups. However, some clinical features, such as fecal property, diarrhea times before hospital treatment shown difference between two groups. The watery stool was more likely found in children, while the blood stool for adults; most of children cases diarrhea ≤3 times before hospital treatment, and adults diarrhea >3 times. Independent risk factor associated with CA-CDI was patients with fever. ST35/RT046 (18.18%), ST54/RT012 (14.55%), ST3/RT001 (14.55%) and ST3/RT009 (12.73%) were the most distributed genotype profiles. ST35/RT046, ST3/RT001 and ST3/RT009 were the commonly found in children patients but ST54/RT012 for adults. The prevalence of CA-CDI in Yunnan province was relatively high, and isolates displayed heterogeneity between children and adults groups.
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