ArticleProceedings of the National Academy of Sciences of the United States of America2018
Conformational transitions of the sodium-dependent sugar transporter, vSGLT.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Revisiting vSGLT: Non-Radioactive Characterization of the Vibrio NaInternational journal of molecular sciences · 2026Article
- Mechanism of substrate recognition and release of human SGLT2.Nature communications · 2025Article
- Molecular mechanisms and computational insights into human SGLTs: advancing toward selective SGLT1 inhibition.Frontiers in molecular biosciences · 2025Review
- They all rock: A systematic comparison of conformational movements in LeuT-fold transporters.Structure (London, England : 1993) · 2024Article
- Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.Nature structural & molecular biology · 2024Article
- Comparison of SGLT1, SGLT2, and Dual Inhibitor biological activity in treating Type 2 Diabetes Mellitus.Advanced therapeutics · 2023Article
- Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.Nature communications · 2023Article
- Structures of human SGLT in the occluded state reveal conformational changes during sugar transport.Nature communications · 2023Article
- Transcriptome Analysis Reveals the Effect of Low NaCl Concentration on Osmotic Stress and Type III Secretion System inInternational journal of molecular sciences · 2023Article
- Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.The Journal of clinical investigation · 2023Article
- Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter.International journal of molecular sciences · 2022Article
- Structural mechanism of SGLT1 inhibitors.Nature communications · 2022Article
- Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modeling of protein conformational changes with Rosetta guided by limited experimental data.Structure (London, England : 1993) · 2022Article
- Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations.The Journal of general physiology · 2021Article
- Function Trumps Form in Two Sugar Symporters,International journal of molecular sciences · 2021Review
- Prokaryotic Solute/Sodium Symporters: Versatile Functions and Mechanisms of a Transporter Family.International journal of molecular sciences · 2021Review
- Active Glucose Transport 2020 and Beyond.Function (Oxford, England) · 2021Article
- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021Review
- Transporters of glucose and other carbohydrates in bacteria.Pflugers Archiv : European journal of physiology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Aviv PazDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90096.
Derek P ClaxtonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Jay Prakash KumarTechnologies for the Advancement of Science, Institute for Stem Cell Biology and Regenerative Medicine, 560065, Bangalore, India.
Kelli KazmierDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Paola BisignanoCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Shruti SharmaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Shannon A NolteMolecular Cell and Developmental Biology Program, University of California, Los Angeles, CA 90095.
Terrin M LiwagMolecular Cell and Developmental Biology Program, University of California, Los Angeles, CA 90095.
Vinod NayakTechnologies for the Advancement of Science, Institute for Stem Cell Biology and Regenerative Medicine, 560065, Bangalore, India.
Ernest M WrightDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90096; ewright@mednet.ucla.edu michael.grabe@ucsf.edu hassane.mchaourab@vanderbilt.edu jabramson@mednet.ucla.edu.ORCID 0000-0002-1023-4391
Michael GrabeCardiovascular Research Institute, University of California, San Francisco, CA 94158; ewright@mednet.ucla.edu michael.grabe@ucsf.edu hassane.mchaourab@vanderbilt.edu jabramson@mednet.ucla.edu.
Hassane S MchaourabDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232; ewright@mednet.ucla.edu michael.grabe@ucsf.edu hassane.mchaourab@vanderbilt.edu jabramson@mednet.ucla.edu.
Jeff AbramsonDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90096; ewright@mednet.ucla.edu michael.grabe@ucsf.edu hassane.mchaourab@vanderbilt.edu jabramson@mednet.ucla.edu.
University of California, Los Angeles · USVanderbilt University · USUniversity of California, San Francisco · USInstitute for Stem Cell Biology and Regenerative Medicine · INUniversity of Trans-Disciplinary Health Sciences and Technology · IN
Funding
Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2010 to 2017
$31.9MStructures of sodium glucose transporters by cryo electron microscopyR01GM078844 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2006 to 2018
$5.3MMOLECULAR MECHANISMS OF INTESTINAL TRANSPORTR01DK019567 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 1986 to 2013
$4.3MComputational Studies of Sodium SymportersR01GM089740 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2011 to 2020
$2.8MFunctional and structural studies of unique pathogenic transporters involved in glycobiologyR01GM124783 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2017 to 2019
$1.3MStructure/Function Studies on the Ca2+: Cation Antiporter family of transportersR21HL093278 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2009 to 2010
$424kNHLBI NIH HHS R21 HL093278NIDDK NIH HHS R01 DK019567NIGMS NIH HHS R01 GM078844NIGMS NIH HHS R01 GM089740NIGMS NIH HHS R01 GM124783NIGMS NIH HHS U54 GM087519
Abstract
Sodium-dependent transporters couple the flow of Na
Indexed as
Bacterial ProteinsBiological Transport, ActiveCysteineElectron Spin Resonance SpectroscopyGalactoseMembrane LipidsMicellesModels, MolecularMolecular Dynamics SimulationMutationProtein ConformationSodiumSodium-Glucose Transport ProteinsVibrio parahaemolyticusBacterial ProteinsCysteineGalactoseMembrane LipidsMicellesSodiumSodium-Glucose Transport ProteinsconformationDEERsugartransportvSGLT
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.