ArticleProceedings of the National Academy of Sciences of the United States of America2018
Dynamic patterns of cortical expansion during folding of the preterm human brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Fetal brain MRI atlases and datasets: A review.NeuroImage · 2024Pooled it
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Surface-based brain age index reflects hematological impacts on cognitive development in children with beta-thalassemia major.iScience · 2026Article
- Brain structure and function in Homo naledi.Brain structure & function · 2026Review
- Fetal MRI reveals altered prenatal cortical surface area in fetuses later diagnosed with autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Article
- A computational model of radial scaffolds in the human fetal brain based on MRI.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Machine learning classification of EEG responses to pain-related vs non-pain-related stimulus in preterm infants.Pain reports · 2025Article
- The Impacts of Enlarged Subarachnoid Space on Brain Growth and Cortex Maturation in Very Preterm Infants.Diagnostics (Basel, Switzerland) · 2025Article
- Longitudinal magnetic resonance imaging reveals differences in cortical expansion in fetuses with congenital heart defects.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Differential patterns of cortical expansion in fetal and preterm brain development.bioRxiv : the preprint server for biology · 2025Article
- The generalizability of cortical area parcellations across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantifying the Timing of Gyral and Sulcal Formation Relative to Growth in the Ferret Cerebral Cortex.Developmental neuroscience · 2025Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
During the third trimester of human brain development, the cerebral cortex undergoes dramatic surface expansion and folding. Physical models suggest that relatively rapid growth of the cortical gray matter helps drive this folding, and structural data suggest that growth may vary in both space (by region on the cortical surface) and time. In this study, we propose a unique method to estimate local growth from sequential cortical reconstructions. Using anatomically constrained multimodal surface matching (aMSM), we obtain accurate, physically guided point correspondence between younger and older cortical reconstructions of the same individual. From each pair of surfaces, we calculate continuous, smooth maps of cortical expansion with unprecedented precision. By considering 30 preterm infants scanned two to four times during the period of rapid cortical expansion (28-38 wk postmenstrual age), we observe significant regional differences in growth across the cortical surface that are consistent with the emergence of new folds. Furthermore, these growth patterns shift over the course of development, with noninjured subjects following a highly consistent trajectory. This information provides a detailed picture of dynamic changes in cortical growth, connecting what is known about patterns of development at the microscopic (cellular) and macroscopic (folding) scales. Since our method provides specific growth maps for individual brains, we are also able to detect alterations due to injury. This fully automated surface analysis, based on tools freely available to the brain-mapping community, may also serve as a useful approach for future studies of abnormal growth due to genetic disorders, injury, or other environmental variables.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.