Evidence map›Paper›PMID 29507144›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Glutathione Conjugation at the Blood-CSF Barrier Efficiently Prevents Exposure of the Developing Brain Fluid Environment to Blood-Borne Reactive Electrophilic Substances.

Ingrid Kratzer, Nathalie Strazielle, Elodie Saudrais, Kati Mönkkönen, Céline Malleval, Sandrine Blondel, Jean-François Ghersi-Egea

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Analgesic Action of Acetaminophen via Kv7 Channels.International journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS.International journal of molecular sciences · 2020
    Review
  11. Brain Barrier Systems Play No Small Roles in Toxicant-induced Brain Disorders.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ingrid KratzerFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France.ORCID 0000-0001-7905-8704
Nathalie StrazielleFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France, jean-francois.ghersi-egea@inserm.fr ns.brain.i@gmail.com.
Elodie SaudraisFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France.
Kati MönkkönenFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France.
Céline MallevalFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France.
Sandrine BlondelBlood-Brain Interfaces Exploratory Platform BIP, Lyon Neurosciences Research Center, 69008 Lyon, France.
Jean-François Ghersi-EgeaFLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, Université Claude Bernard Lyon-1, 69008 Lyon, France, jean-francois.ghersi-egea@inserm.fr ns.brain.i@gmail.com.
Université Claude Bernard Lyon 1 · FRCentre de Recherche en Neurosciences de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure of the developing brain to toxins, drugs, or deleterious endogenous compounds during the perinatal period can trigger alterations in cell division, migration, differentiation, and synaptogenesis, leading to lifelong neurological impairment. The brain is protected by cellular barriers acting through multiple mechanisms, some of which are still poorly explored. We used a combination of enzymatic assays, live tissue fluorescence microscopy, and an

Indexed as

AnimalsBlood-Brain BarrierChoroid PlexusEpendymaFemaleFree RadicalsGlutathioneGlutathione TransferaseMaleRatsRats, Sprague-DawleyFree RadicalsGlutathioneGlutathione Transferaseblood–brain barriersbrain homeostasisglutathione S-transferasesneuroprotectionoxidative stressperinatal

Identifiers

PMID29507144
PMCPMC6596044
OpenAlexW2789459505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.