Evidence map›Paper›PMID 29507111›Full record

ArticleJournal of cell science2018

Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart.

David K Jones, Ashley C Johnson, Elon C Roti Roti, Fang Liu, Rebecca Uelmen, Rebecca A Ayers, Istvan Baczko, David J Tester, Michael J Ackerman, Matthew C Trudeau and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

David K JonesDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA.
Ashley C JohnsonDepartment of Physiology, University of Maryland School of Medicine, 660 W. Redwood St., Baltimore, MD 21201, USA.
Elon C Roti RotiDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA.ORCID 0000-0002-0526-9223
Fang LiuDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA.
Rebecca UelmenDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA.ORCID 0000-0001-7888-2582
Rebecca A AyersDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA.
Istvan BaczkoDepartment of Pharmacology and Pharmacotherapy, University of Szeged, Szeged 6720, Hungary.
David J TesterDepartment of Cardiovascular Diseases, Division of Heart Rhythm Service, Mayo Clinic, Rochester, NY 55905, USA.
Michael J AckermanDepartment of Cardiovascular Diseases, Division of Heart Rhythm Service, Mayo Clinic, Rochester, NY 55905, USA.
Matthew C TrudeauDepartment of Physiology, University of Maryland School of Medicine, 660 W. Redwood St., Baltimore, MD 21201, USA garobert@wisc.edu mtrudeau@som.umaryland.edu.
Gail A RobertsonDepartment of Neuroscience, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison SMPH, 1111 Highland Ave. #5505, Madison, WI 53705, USA garobert@wisc.edu mtrudeau@som.umaryland.edu.ORCID 0000-0003-4694-5790
University of Wisconsin–Madison · USMayo Clinic · USUniversity of Maryland, Baltimore · USUniversity of Szeged · HU

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Translational Control of Cardiac ExcitabilityR01HL131403 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Gail A Robertson · 2016 to 2026
$6.0M
hERG Channel Assembly and TraffickingR01HL081780 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, GAIL A · 2005 to 2014
$3.2M
Domain-specific gating modulation to restore action potential duration in long QT patient-derived cardiomyocytesK99HL133482 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JONES, DAVID K. · 2017 to 2018
$197k
The F-actin binding protein TRIOBP-1 regulates hERG K+ channelsF32HL131189 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JOHNSON, ASHLEY ANN · 2016 to 2016
$56k
NHLBI NIH HHS F32 HL131189NHLBI NIH HHS K99 HL133482NHLBI NIH HHS R01 HL081780NHLBI NIH HHS R01 HL131403NHLBI NIH HHS T32 HL007936
6 · The paper itself

Abstract

Reduced levels of the cardiac human (h)ERG ion channel protein and the corresponding repolarizing current

Indexed as

AnimalsCalciumHEK293 CellsHumansMaleMicrofilament ProteinsMyocytes, CardiacProtein BindingProtein TransportRatsTranscriptional Regulator ERGCalciumERG protein, humanMicrofilament ProteinsTranscriptional Regulator ERGTRIOBP protein, humanAction potentialFRETIKriPSC-CMKCNH2TARAYeast two-hybrid

Identifiers

PMID29507111
PMCPMC5897710
OpenAlexW2792266541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.