Evidence map›Paper›PMID 29507109›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.

Toolika Singh, Michaela Fakiola, Joyce Oommen, Akhil Pratap Singh, Abhishek K Singh, Noel Smith, Jaya Chakravarty, Shyam Sundar, Jenefer M Blackwell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Analysis of HLA Alleles in Different Cohorts of Patients Infected byInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Spatial and Temporal Variability of Visceral Leishmaniasis in Colombia, 2007 to 2018.The American journal of tropical medicine and hygiene · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Genetics, Transcriptomics and Meta-Taxonomics in Visceral Leishmaniasis.Frontiers in cellular and infection microbiology · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Toolika SinghInstitute of Medical Sciences, Banaras Hindu University, Varanasi OS 221 005, India.ORCID 0000-0002-0324-7821
Michaela FakiolaDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom.
Joyce OommenTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia 6008, Australia; and.
Akhil Pratap SinghInstitute of Medical Sciences, Banaras Hindu University, Varanasi OS 221 005, India.
Abhishek K SinghInstitute of Medical Sciences, Banaras Hindu University, Varanasi OS 221 005, India.
Noel SmithLonza Biologics PLC, Great Abington, Cambridge CB21 6GS, United Kingdom.
Jaya ChakravartyInstitute of Medical Sciences, Banaras Hindu University, Varanasi OS 221 005, India.
Shyam SundarInstitute of Medical Sciences, Banaras Hindu University, Varanasi OS 221 005, India.ORCID 0000-0001-9988-582X
Jenefer M BlackwellDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom; jenefer.blackwell@telethonkids.org.au.ORCID 0000-0002-0784-7277
Institute of Medical Sciences · INThe Kids Research Institute Australia · AULonza (United Kingdom) · GBUniversity of Cambridge · GB

Funding

Visceral Leishmaniasis in Bihar State, IndiaP50AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2007 to 2016
$6.4M
Visceral Leishmaniasis in Bihar State, IndiaU19AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2017 to 2021
$2.8M
NIAID NIH HHS P50 AI074321NIAID NIH HHS U19 AI074321
6 · The paper itself

Abstract

HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in 889 human cases and 977 controls from India. NetMHCIIpan 2.1 was used to map epitopes and binding affinities across 49

Indexed as

AdolescentAdultAllelesChildEpitopesFemaleHLA-DRB1 ChainsHumansInterleukin-10Leishmaniasis, VisceralMaleMiddle AgedProtein BindingYoung AdultEpitopesHLA-DRB1 ChainsInterleukin-10

Identifiers

PMID29507109
PMCPMC5893436
OpenAlexW2790157620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.