Evidence map›Paper›PMID 29507095›Full record

ArticleThe Journal of biological chemistry2018

Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice.

Tomoya Sakabe, Keiko Sakai, Toru Maeda, Ataru Sunaga, Nao Furuta, Ronen Schweitzer, Takako Sasaki, Takao Sakai

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 132 citations in OpenAlex.

  1. Article
  2. PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx-Lineage Cells Accelerates Structural and Functional Recovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. The Secretome From Mechanically Loaded Myoblasts Enhances Tenocyte-Mediated Wound Healing in a 3D In Vitro Tendon Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. A latent Axin2NPJ Regenerative medicine · 2024
    Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Tomoya SakabeFrom the Medical Research Council Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom.
Keiko SakaiFrom the Medical Research Council Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom.
Toru MaedaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Ataru SunagaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Nao FurutaFrom the Medical Research Council Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom.
Ronen SchweitzerResearch Division, Shriners Hospital for Children, Portland, Oregon 97239, and.
Takako SasakiDepartment of Biochemistry, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Takao SakaiFrom the Medical Research Council Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom, sakait@liverpool.ac.uk.
Cleveland Clinic Lerner College of Medicine · USMedical Research Council · GBOita University · JPShriners Hospitals for Children - Portland · US

Funding

Fibronectin deposition and TGF-beta activation in liver fibrosisR01DK074538 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI SAKAI, TAKAO · 2007 to 2011
$1.5M
NIDDK NIH HHS R01 DK074538
6 · The paper itself

Abstract

Tendon is a dense connective tissue that transmits high mechanical forces from skeletal muscle to bone. The transcription factor scleraxis (Scx) is a highly specific marker of both precursor and mature tendon cells (tenocytes). Mice lacking

Indexed as

Wound HealingAchilles TendonAnimalsBasic Helix-Loop-Helix ProteinsCell LineageCell MovementExtracellular MatrixGene DeletionMiceMice, TransgenicSignal TransductionStem CellsTendon InjuriesTransforming Growth Factor betaTransgenesBasic Helix-Loop-Helix ProteinsScx protein, mouseTransforming Growth Factor betacell biologyconditional knockoutextracellular matrixmouse geneticsscleraxistendontissue progenitor cellstransforming growth factor β (TGF-β)wound healing

Identifiers

PMID29507095
PMCPMC5912447
OpenAlexW2791532651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.